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Osteological, Biomolecular and Geochemical Examination of an Early Anglo-Saxon Case of Lepromatous Leprosy

Inskip, SA, Taylor, GM, Zakrzewski, SR, Mays, SA, Pike, AWG, Llewellyn, G, Williams, CM, Lee, OY-C, Wu, HHT, Minnikin, DE, Besra, GS and Stewart, GR (2015) Osteological, Biomolecular and Geochemical Examination of an Early Anglo-Saxon Case of Lepromatous Leprosy PLOS ONE, 10 (5), ARTN e.

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Abstract

We have examined a 5th to 6th century inhumation from Great Chesterford, Essex, UK. The incomplete remains are those of a young male, aged around 21-35 years at death. The remains show osteological evidence of lepromatous leprosy (LL) and this was confirmed by lipid biomarker analysis and ancient DNA (aDNA) analysis, which provided evidence for both multi-copy and single copy loci from the Mycobacterium leprae genome. Genotyping showed the strain belonged to the 3I lineage, but the Great Chesterford isolate appeared to be ancestral to 3I strains found in later medieval cases in southern Britain and also continental Europe. While a number of contemporaneous cases exist, at present, this case of leprosy is the earliest radiocarbon dated case in Britain confirmed by both aDNA and lipid biomarkers. Importantly, Strontium and Oxygen isotope analysis suggest that the individual is likely to have originated from outside Britain. This potentially sheds light on the origins of the strain in Britain and its subsequent spread to other parts of the world, including the Americas where the 3I lineage of M. leprae is still found in some southern states of America.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences
Authors :
AuthorsEmailORCID
Inskip, SAUNSPECIFIEDUNSPECIFIED
Taylor, GMUNSPECIFIEDUNSPECIFIED
Zakrzewski, SRUNSPECIFIEDUNSPECIFIED
Mays, SAUNSPECIFIEDUNSPECIFIED
Pike, AWGUNSPECIFIEDUNSPECIFIED
Llewellyn, GUNSPECIFIEDUNSPECIFIED
Williams, CMUNSPECIFIEDUNSPECIFIED
Lee, OY-CUNSPECIFIEDUNSPECIFIED
Wu, HHTUNSPECIFIEDUNSPECIFIED
Minnikin, DEUNSPECIFIEDUNSPECIFIED
Besra, GSUNSPECIFIEDUNSPECIFIED
Stewart, GRUNSPECIFIEDUNSPECIFIED
Date : 13 May 2015
Identification Number : 10.1371/journal.pone.0124282
Uncontrolled Keywords : Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, MYCOBACTERIUM-LEPRAE, ISOTOPIC COMPOSITION, EARLY BRITAIN, MEDIEVAL, TUBERCULOSIS, SAMPLES, TANDEM, AMS, PRETREATMENT, PHOSPHATE
Related URLs :
Additional Information : Copyright 2015 Public Library of Science
Depositing User : Symplectic Elements
Date Deposited : 20 Oct 2015 13:51
Last Modified : 20 Oct 2015 13:51
URI: http://epubs.surrey.ac.uk/id/eprint/808669

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