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DEM analysis of the effect of particle-wall impact on the dispersion performance in carrier-based dry powder inhalers

Yang, J, Wu, C-Y and Adams, M (2015) DEM analysis of the effect of particle-wall impact on the dispersion performance in carrier-based dry powder inhalers INTERNATIONAL JOURNAL OF PHARMACEUTICS, 487 (1-2). pp. 32-38.

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Abstract

The impact between particles or agglomerates and a device wall is considered as an important mechanism controlling the dispersion of active pharmaceutical ingredient (API) particles in dry powder inhalers (DPIs). In order to characterise the influencing factors and better understand the impact induced dispersion process for carrier-based DPIs, the impact behaviour between an agglomerate and a wall is systematically investigated using the discrete element method. In this study, a carrier-based agglomerate is initially formed and then allowed to impact with a target wall. The effects of impact velocity, impact angle and work of adhesion on the dispersion performance are analysed. It is shown that API particles in the near-wall regions are more likely to be dispersed due to the deceleration of the carrier particle resulted from the impact with the wall. It is also revealed that the dispersion ratio increases with increasing impact velocity and impact angle, indicating that the normal component of the impact velocity plays a dominant role on the dispersion. Furthermore, the impact induced dispersion performance for carrier-based DPI formulations can be well approximated using a cumulative Weibull distribution function that is governed by the ratio of overall impact energy and adhesion energy.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
AuthorsEmailORCID
Yang, JUNSPECIFIEDUNSPECIFIED
Wu, C-YUNSPECIFIEDUNSPECIFIED
Adams, MUNSPECIFIEDUNSPECIFIED
Date : 20 June 2015
Identification Number : 10.1016/j.ijpharm.2015.04.006
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Impact, Adhesion, Dispersion, Discrete element method, Dry powder inhalation, PARTICULATE SYSTEMS, FINE PARTICLES, SIMULATION, BREAKAGE, FORMULATIONS, INHALATION, ADHESIVE, SPHERES, DESIGN, ANGLE
Related URLs :
Additional Information : © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 20 Oct 2015 12:43
Last Modified : 20 Jun 2016 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/808586

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