Applications of dielectrophoretic/electro-hydrodynamic "zipper" electrodes for detection of biological nanoparticles

Hubner, Y, Hoettges, KF, McDonnell, MB, Carter, MJ and Hughes, MP (2007) Applications of dielectrophoretic/electro-hydrodynamic "zipper" electrodes for detection of biological nanoparticles INTERNATIONAL JOURNAL OF NANOMEDICINE, 2 (3). pp. 427-431.

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Abstract

A major problem for surface-based detection techniques such as surface plasmon resonance and quartz crystal microbalances is that at low concentrations, diffusion is an insufficient driving force to bring colloidal submicron-scale particles to the detection surface. In order to overcome this, it has previously been demonstrated that a combination of dielectrophoresis and AC-electro-hydrodynamic flow can be used to focus cell-sized particles from suspension onto a large metal surface, in order to improve the detection capabilities of such systems. In this paper we describe how the combination of these two phenomena, using the so-called “zipper” electrode array, can be used to concentrate a wide range of nanoparticles of biological interest, such as influenza virus, dissolved albumin, and DNA molecules as well as latex beads of various sizes. We also demonstrate that the speed at which particles are transported towards the centre of the electrode pads by dielectrophoresis and electro-hydrodynamic flow is not related to the particle size for colloidal particles.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :	Hubner, Y, Hoettges, KF, McDonnell, MB, Carter, MJ and Hughes, MP
Date :	1 January 2007
Uncontrolled Keywords :	Science & Technology, Life Sciences & Biomedicine, Nanoscience & Nanotechnology, Pharmacology & Pharmacy, Science & Technology - Other Topics, NANOSCIENCE & NANOTECHNOLOGY, PHARMACOLOGY & PHARMACY, electro-hydrodynamic flow, dielectrophoresis, influenza, DNA, MICROELECTRODES, ELECTROLYTES, COMBINATION, FORCES, FIELDS
Related URLs :	Author
Additional Information :	CC-BY License. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
Depositing User :	Symplectic Elements
Date Deposited :	07 Oct 2015 14:46
Last Modified :	06 Jul 2019 05:14
URI:	http://epubs.surrey.ac.uk/id/eprint/808536

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