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Protein adsorption on materials for recording sites on implantable microelectrodes

Selvakumaran, J, Keddie, JL, Ewins, DJ and Hughes, MP (2008) Protein adsorption on materials for recording sites on implantable microelectrodes JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 19 (1). pp. 143-151.

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Abstract

Implantable microelectrodes have the potential to become part of neural prostheses to restore lost nerve function after nerve damage. The initial adsorption of proteins to materials for implantable microelectrodes is an important factor in determining the longevity and stability of the implant. Once an implant is in the body, protein adsorption takes place almost instantly before the cells reach the surface of an implant. The aim of this study was to identify an optimum material for electrode recording sites on implantable microelectrodes. Common materials for electrode sites are gold, platinum, iridium, and indium tin oxide. These, along with a reference material (titanium), were investigated. The thickness and the structure of adsorbed proteins on these materials were measured using a combination of atomic force microscopy and ellipsometry. The adsorbed protein layers on gold (after 7 and 28 days of exposure to serum) were the smoothest and the thinnest compared to all the other substrate materials, indicating that gold is the material of choice for electrode recording sites on implantable microelectrodes. However, the results also show that indium tin oxide might also be a good choice for these applications.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
AuthorsEmailORCID
Selvakumaran, JUNSPECIFIEDUNSPECIFIED
Keddie, JLUNSPECIFIEDUNSPECIFIED
Ewins, DJUNSPECIFIEDUNSPECIFIED
Hughes, MPUNSPECIFIEDUNSPECIFIED
Date : 1 January 2008
Identification Number : 10.1007/s10856-007-3110-x
Uncontrolled Keywords : Science & Technology, Technology, Engineering, Biomedical, Materials Science, Biomaterials, Engineering, Materials Science, ENGINEERING, BIOMEDICAL, MATERIALS SCIENCE, BIOMATERIALS, microelectrodes, implantable, metals, protein adsorption, recording sites, ellipsometry, SILICON-BASED MICROELECTRODES, MULTISITE MICROPROBES, ELECTRODE ARRAY, SURFACES, NERVE, ELLIPSOMETRY, STIMULATION, BIOCOMPATIBILITY, NEUROPHYSIOLOGY, SPECTROSCOPY
Related URLs :
Additional Information : The final publication is available at link.springer.com
Depositing User : Symplectic Elements
Date Deposited : 06 Oct 2015 10:06
Last Modified : 06 Oct 2015 10:06
URI: http://epubs.surrey.ac.uk/id/eprint/808508

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