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Dielectrophoretic Response of DNA Shows Different Conduction Mechanisms for Poly(dG)-Poly(dC) and Poly(dA)-Poly(dT) in Solution

Mohamad, AS, Jeynes, JCG and Hughes, MP (2014) Dielectrophoretic Response of DNA Shows Different Conduction Mechanisms for Poly(dG)-Poly(dC) and Poly(dA)-Poly(dT) in Solution IEEE TRANSACTIONS ON NANOBIOSCIENCE, 13 (1). pp. 51-54.

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Abstract

Although the subject of some scrutiny over the years, the mechanism of conduction in DNA has not yet been resolved, with competing theories suggesting either electronic and ionic conduction mechanisms. In this paper we use dielectrophoresis to determine the electrical properties of poly(dG)-poly(dC) (GC) and poly(dA)-poly(dT) (AT) DNA in solution. The molecules show different conduction mechanisms; GC DNA exhibits conduction primarily through the molecule, whereas in AT DNA conduction through the counterion cloud surrounding the molecule in solution is more significant.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
AuthorsEmailORCID
Mohamad, ASUNSPECIFIEDUNSPECIFIED
Jeynes, JCGUNSPECIFIEDUNSPECIFIED
Hughes, MPUNSPECIFIEDUNSPECIFIED
Date : 1 March 2014
Identification Number : 10.1109/TNB.2014.2299215
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Biochemical Research Methods, Nanoscience & Nanotechnology, Biochemistry & Molecular Biology, Science & Technology - Other Topics, BIOCHEMICAL RESEARCH METHODS, NANOSCIENCE & NANOTECHNOLOGY, Bioelectric phenomena, dielectrophoresis, DNA, electrokinetic, molecular biophysics, DOUBLE-STRANDED DNA, AQUEOUS-SOLUTION, MOLECULES, MANIPULATION, POTENTIALS, TRANSPORT, BEHAVIOR
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Additional Information : (c) 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.
Depositing User : Symplectic Elements
Date Deposited : 25 Sep 2015 17:44
Last Modified : 25 Sep 2015 17:44
URI: http://epubs.surrey.ac.uk/id/eprint/808500

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