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Efficient dielectrophoretic cell enrichment using a dielectrophoresis-well based system

Razak, MAA, Hoettges, KF, Fatoyinbo, HO, Labeed, FH and Hughes, MP (2013) Efficient dielectrophoretic cell enrichment using a dielectrophoresis-well based system BIOMICROFLUIDICS, 7 (6), ARTN 0.

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Abstract

Whilst laboratory-on-chip cell separation systems using dielectrophoresis are increasingly reported in the literature, many systems are afflicted by factors which impede "real world" performance, chief among these being cell loss (in dead spaces, attached to glass and tubing surfaces, or sedimentation from flow), and designs with large channel height-to-width ratios (large channel widths, small channel heights) that make the systems difficult to interface with other microfluidic systems. In this paper, we present a scalable structure based on 3D wells with approximately unity height-to-width ratios (based on tubes with electrodes on the sides), which is capable of enriching yeast cell populations whilst ensuring that up to 94.3% of cells processed through the device can be collected in tubes beyond the output.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
AuthorsEmailORCID
Razak, MAAUNSPECIFIEDUNSPECIFIED
Hoettges, KFUNSPECIFIEDUNSPECIFIED
Fatoyinbo, HOUNSPECIFIEDUNSPECIFIED
Labeed, FHUNSPECIFIEDUNSPECIFIED
Hughes, MPUNSPECIFIEDUNSPECIFIED
Date : 1 November 2013
Identification Number : 10.1063/1.4842395
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemical Research Methods, Biophysics, Nanoscience & Nanotechnology, Physics, Fluids & Plasmas, Biochemistry & Molecular Biology, Science & Technology - Other Topics, Physics, BIOPHYSICS, NANOSCIENCE & NANOTECHNOLOGY, PHYSICS, FLUIDS & PLASMAS, SEPARATION
Related URLs :
Additional Information : Copyright (2013) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.The following article appeared in Biomicrofluidics and may be found at http://scitation.aip.org.
Depositing User : Symplectic Elements
Date Deposited : 06 Oct 2015 10:57
Last Modified : 06 Oct 2015 10:57
URI: http://epubs.surrey.ac.uk/id/eprint/808498

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