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Liquids that form due to dynamics of the molecules that depend on the local density

Sear, RP (2015) Liquids that form due to dynamics of the molecules that depend on the local density arXiv.

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Abstract

RNA molecules in living cells form what look like liquid droplets formed by liquid/liquid phase separation. But unlike the molecules in conventional phase separating mixtures, RNA molecules are transported by molecular motors that consume energy and so are out of equilibrium. Motivated by this we consider what sort of simple rules for the dynamics of model mRNA molecules lead to liquid/liquid phase separation. We find that dynamics that slow as the local density of molecules increases, drive the formation of liquids. We also look at the analogous separation of the two blocks of a block copolymer, in which the monomers of one block have dynamics that depend on the local density of monomers of that block. We find that this block condenses and separates from the monomers of the other block. This is a simple model of the out-of-equilibrium domain formation found in the chromatin in the nucleus of cells.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
AuthorsEmailORCID
Sear, RPUNSPECIFIEDUNSPECIFIED
Date : 24 March 2015
Uncontrolled Keywords : cond-mat.soft, cond-mat.soft, physics.bio-ph, q-bio.SC
Related URLs :
Additional Information : This is an arXiv publication.
Depositing User : Symplectic Elements
Date Deposited : 25 Aug 2015 09:12
Last Modified : 25 Aug 2015 09:12
URI: http://epubs.surrey.ac.uk/id/eprint/808302

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