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Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment.

Betson, M, Sousa-Figueiredo, JC, Atuhaire, A, Arinaitwe, M, Adriko, M, Mwesigwa, G, Nabonge, J, Kabatereine, NB, Sutherland, CJ and Stothard, JR (2014) Detection of persistent Plasmodium spp. infections in Ugandan children after artemether-lumefantrine treatment. Parasitology, 141 (14). pp. 1880-1890.

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Abstract

During a longitudinal study investigating the dynamics of malaria in Ugandan lakeshore communities, a consistently high malaria prevalence was observed in young children despite regular treatment. To explore the short-term performance of artemether-lumefantrine (AL), a pilot investigation into parasite carriage after treatment(s) was conducted in Bukoba village. A total of 163 children (aged 2-7 years) with a positive blood film and rapid antigen test were treated with AL; only 8.7% of these had elevated axillary temperatures. On day 7 and then on day 17, 40 children (26.3%) and 33 (22.3%) were positive by microscopy, respectively. Real-time PCR analysis demonstrated that multi-species Plasmodium infections were common at baseline, with 41.1% of children positive for Plasmodium falciparum/Plasmodium malariae, 9.2% for P. falciparum/ Plasmodium ovale spp. and 8.0% for all three species. Moreover, on day 17, 39.9% of children infected with falciparum malaria at baseline were again positive for the same species, and 9.2% of those infected with P. malariae at baseline were positive for P. malariae. Here, chronic multi-species malaria infections persisted in children after AL treatment(s). Better point-of-care diagnostics for non-falciparum infections are needed, as well as further investigation of AL performance in asymptomatic individuals.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences
Authors :
AuthorsEmailORCID
Betson, MUNSPECIFIEDUNSPECIFIED
Sousa-Figueiredo, JCUNSPECIFIEDUNSPECIFIED
Atuhaire, AUNSPECIFIEDUNSPECIFIED
Arinaitwe, MUNSPECIFIEDUNSPECIFIED
Adriko, MUNSPECIFIEDUNSPECIFIED
Mwesigwa, GUNSPECIFIEDUNSPECIFIED
Nabonge, JUNSPECIFIEDUNSPECIFIED
Kabatereine, NBUNSPECIFIEDUNSPECIFIED
Sutherland, CJUNSPECIFIEDUNSPECIFIED
Stothard, JRUNSPECIFIEDUNSPECIFIED
Date : 16 May 2014
Identification Number : 10.1017/S003118201400033X
Related URLs :
Additional Information : © Cambridge University Press 2014. The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence http://creativecommons.org/licenses/by/3.0/ doi:10.1017/S003118201400033X
Depositing User : Symplectic Elements
Date Deposited : 11 Aug 2015 14:20
Last Modified : 11 Aug 2015 14:20
URI: http://epubs.surrey.ac.uk/id/eprint/808135

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