Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children.

Betson, M, Sousa-Figueiredo, JC, Kabatereine, NB and Stothard, JR (2012) Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children. Am J Trop Med Hyg, 87 (4). pp. 694-700.

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Abstract

There is a need for field-applicable markers to assess morbidity associated with intestinal schistosomiasis, especially in the context of preventive chemotherapy in young children. We investigated whether fecal occult blood (FOB) point-of-care tests could be used to assess intestinal pathology over a 12-month period in a cohort of 382 children (< 5 years of age). We found a strong association between egg-patent schistosomiasis and FOB at baseline (odds ratio [OR] = 3.1, P < 0.0001), 6 months (OR = 3.4, P < 0.0001), and 12 months (OR = 3.5, P < 0.0001), despite repeated chemotherapy. There were tendencies for prevalence of FOB to decrease in children who became egg negative and increase in those who became egg positive. Our results demonstrate overt disease in children less than five years of age. We therefore propose that FOB is useful for assessing dynamics of intestinal morbidity in young children at the community level and monitoring changes in morbidity after mass chemotherapy.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Betson, M Sousa-Figueiredo, JC Kabatereine, NB Stothard, JR
Date :	October 2012
Identification Number :	10.4269/ajtmh.2012.12-0059
Uncontrolled Keywords :	Animals, Anthelmintics, Child, Preschool, Feces, Female, Humans, Infant, Male, Morbidity, Occult Blood, Parasite Egg Count, Point-of-Care Systems, Praziquantel, Prevalence, Schistosoma mansoni, Schistosomiasis mansoni, Uganda
Related URLs :	Author
Additional Information :	Copyright © 2012 by The American Society of Tropical Medicine and Hygiene
Depositing User :	Symplectic Elements
Date Deposited :	14 Aug 2015 09:22
Last Modified :	31 Oct 2017 17:33
URI:	http://epubs.surrey.ac.uk/id/eprint/808128

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