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Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study

von Schantz, M, Taporoski, TP, Horimoto, ARVR, Duarte, NE, Vallada, H, Krieger, JE, Pedrazzoli, M, Negrao, AB and Pereira, AC (2015) Distribution and heritability of diurnal preference (chronotype) in a rural Brazilian family-based cohort, the Baependi study SCIENTIFIC REPORTS, 5, 9214.

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Abstract

Diurnal preference (chronotype) is a useful instrument for studying circadian biology in humans. It harbours trait-like dimensions relating to circadian period and sleep homeostasis, but also has ontogenetic components (morningness increases with age). We used the Morningness-Eveningness questionnaire (MEQ) in the Baependi study, a family-based cohort study based in a small town in Minas Gerais, Brazil. The population is highly admixed and has a cohesive and conservative lifestyle. 825 individuals (497 female) aged 18–89 years (average ± SD = 46.4 ± 16.3) and belonging to 112 different families participated in this study. The average MEQ score was 63.5 ± 11.2 with a significant (P < 0.0001) linear increase with age. Morningness was significantly (P < 0.0001) higher in the rural (70.2 ± 9.8) than in the municipal zone (62.6 ± 11.1), and was also significantly (P = 0.025) higher in male (64.6 ± 10.9) than in female (62.8 ± 11.2) participants. Thus, in spite of universal access to electricity, the Baependi population was strongly shifted towards morningness, particularly in the rural zone. Heritability of MEQ score was 0.48 when adjusted for sex and age, or 0.38 when adjusted for sex, age, and residential zone. The reported MEQ score heritability is more akin to those of previous twin studies than previous family studies.

Item Type: Article
Subjects : Biosciences
Divisions : Faculty of Health and Medical Sciences
Authors :
AuthorsEmailORCID
von Schantz, MUNSPECIFIEDUNSPECIFIED
Taporoski, TPUNSPECIFIEDUNSPECIFIED
Horimoto, ARVRUNSPECIFIEDUNSPECIFIED
Duarte, NEUNSPECIFIEDUNSPECIFIED
Vallada, HUNSPECIFIEDUNSPECIFIED
Krieger, JEUNSPECIFIEDUNSPECIFIED
Pedrazzoli, MUNSPECIFIEDUNSPECIFIED
Negrao, ABUNSPECIFIEDUNSPECIFIED
Pereira, ACUNSPECIFIEDUNSPECIFIED
Date : 18 March 2015
Identification Number : 10.1038/srep09214
Copyright Disclaimer : This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission fromthe license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords : Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, SLEEP-WAKE CYCLE, MORNINGNESS-EVENINGNESS QUESTIONNAIRE, HUMAN CIRCADIAN PACEMAKER, AGE-RELATED-CHANGE, PER3 POLYMORPHISM, PHASE SYNDROME, GENE, CLOCK, POPULATION, PERIOD
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 01 Jun 2016 14:22
Last Modified : 01 Jun 2016 14:22
URI: http://epubs.surrey.ac.uk/id/eprint/807951

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