University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Circadian Regulation of Slow Waves in Human Sleep: Topographical Aspects

Lazar, AS, Lazar, ZI and Dijk, DJ (2015) Circadian Regulation of Slow Waves in Human Sleep: Topographical Aspects Neuroimage, 116. pp. 123-134.

[img] Text
Circadian regulation of slow wave in human seeep_Lazar_Neuroimage2015_maintext.doc
Available under License : See the attached licence file.

Download (544kB)
[img] Text
Circadian regulation of slow wave in human seeep_Lazar_Neuroimage2015_Supplementary.doc
Available under License : See the attached licence file.

Download (3MB)
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

Slow waves (SWs, 0.5–4 Hz) in field potentials during sleep reflect synchronized alternations between bursts of action potentials and periods of membrane hyperpolarization of cortical neurons. SWs decline during sleep and this is thought to be related to a reduction of synaptic strength in cortical networks and to be central to sleep's role in maintaining brain function. A central assumption in current concepts of sleep function is that SWs during sleep, and associated recovery processes, are independent of circadian rhythmicity. We tested this hypothesis by quantifying all SWs from 12 EEG derivations in 34 participants in whom 231 sleep periods were scheduled across the circadian cycle in a 10-day forced-desynchrony protocol which allowed estimation of the separate circadian and sleep-dependent modulation of SWs. Circadian rhythmicity significantly modulated the incidence, amplitude, frequency and the slope of the SWs such that the peaks of the circadian rhythms in these slow-wave parameters were located during the biological day. Topographical analyses demonstrated that the sleep-dependent modulation of SW characteristics was most prominent in frontal brain areas whereas the circadian effect was similar to or greater than the sleep-dependent modulation over the central and posterior brain regions. The data demonstrate that circadian rhythmicity directly modulates characteristics of SWs thought to be related to synaptic plasticity and that this modulation depends on topography. These findings have implications for the understanding of local sleep regulation and conditions such as ageing, depression, and neurodegeneration which are associated with changes in SWs, neural plasticity and circadian rhythmicity.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Lazar, ASUNSPECIFIEDUNSPECIFIED
Lazar, ZIUNSPECIFIEDUNSPECIFIED
Dijk, DJUNSPECIFIEDUNSPECIFIED
Date : 11 May 2015
Identification Number : 10.1016/j.neuroimage.2015.05.012
Additional Information : © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 16 Sep 2015 16:33
Last Modified : 01 Aug 2016 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/807658

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800