University of Surrey

Test tubes in the lab Research in the ATI Dance Research

The UK Heart Spare Study (Stage IB): Randomised comparison of a voluntary breath-hold technique and prone radiotherapy after breast conserving surgery

Bartlett, FR, Colgan, RM, Donovan, Ellen, McNair, HA, Carr, K, Evans, PM, Griffin, C, Locke, I, Haviland, JS, Yarnold, JR and Kirby, AM (2014) The UK Heart Spare Study (Stage IB): Randomised comparison of a voluntary breath-hold technique and prone radiotherapy after breast conserving surgery Radiotherapy and Oncology, 114 (1). pp. 66-72.

[img]
Preview
Text
Heartspare IB.pdf - Accepted version Manuscript
Available under License : See the attached licence file.

Download (1MB) | Preview
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

Purpose To compare mean heart and left anterior descending coronary artery (LAD) doses (NTDmean) and positional reproducibility in larger-breasted women receiving left breast radiotherapy using supine voluntary deep-inspiratory breath-hold (VBH) and free-breathing prone techniques. Materials and methods Following surgery for early breast cancer, patients with estimated breast volumes >750 cm3 underwent planning-CT scans in supine VBH and free-breathing prone positions. Radiotherapy treatment plans were prepared, and mean heart and LAD doses were calculated. Patients were randomised to receive one technique for fractions 1–7, before switching techniques for fractions 8–15 (40 Gy/15 fractions total). Daily electronic portal imaging and alternate-day cone-beam CT (CBCT) imaging were performed. The primary endpoint was the difference in mean LAD NTDmean between techniques. Population systematic (Σ) and random errors (σ) were estimated. Within-patient comparisons between techniques used Wilcoxon signed-rank tests. Results 34 patients were recruited, with complete dosimetric data available for 28. Mean heart and LAD NTDmean doses for VBH and prone treatments respectively were 0.4 and 0.7 (p < 0.001) and 2.9 and 7.8 (p < 0.001). Clip-based CBCT errors for VBH and prone respectively were ⩽3.0 mm and ⩽6.5 mm (Σ) and ⩽3.5 mm and ⩽5.4 mm (σ). Conclusions In larger-breasted women, supine VBH provided superior cardiac sparing and reproducibility than a free-breathing prone position.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Centre for Vision Speech and Signal Processing
Authors :
NameEmailORCID
Bartlett, FRUNSPECIFIEDUNSPECIFIED
Colgan, RMUNSPECIFIEDUNSPECIFIED
Donovan, Ellene.donovan@surrey.ac.ukUNSPECIFIED
McNair, HAUNSPECIFIEDUNSPECIFIED
Carr, KUNSPECIFIEDUNSPECIFIED
Evans, PMUNSPECIFIEDUNSPECIFIED
Griffin, CUNSPECIFIEDUNSPECIFIED
Locke, IUNSPECIFIEDUNSPECIFIED
Haviland, JSUNSPECIFIEDUNSPECIFIED
Yarnold, JRUNSPECIFIEDUNSPECIFIED
Kirby, AMUNSPECIFIEDUNSPECIFIED
Date : 26 November 2014
Identification Number : 10.1016/j.radonc.2014.11.018
Copyright Disclaimer : © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Oncology, Radiology, Nuclear Medicine & Medical Imaging, Radiotherapy, Breast cancer, Cardiac dose, Prone, Breath-hold, CORONARY-ARTERY, CONFORMAL RADIOTHERAPY, HELICAL TOMOTHERAPY, PENDULOUS BREASTS, CANCER PATIENTS, IRRADIATION, SUPINE, REDUCTION, RADIATION, POSITION
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 06 May 2015 15:54
Last Modified : 22 Aug 2017 09:48
URI: http://epubs.surrey.ac.uk/id/eprint/807369

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800