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Lempel-Ziv complexity of cortical activity during sleep and waking in rats.

Abásolo, D, Simons, S, Morgado da Silva, R, Tononi, G and Vyazovskiy, VV (2015) Lempel-Ziv complexity of cortical activity during sleep and waking in rats. J Neurophysiol, 113 (7). pp. 2742-2752.

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Abstract

Understanding the dynamics of brain activity manifested in the EEG, local field potentials (LFP), and neuronal spiking is essential for explaining their underlying mechanisms and physiological significance. Much has been learned about sleep regulation using conventional EEG power spectrum, coherence, and period-amplitude analyses, which focus primarily on frequency and amplitude characteristics of the signals and on their spatio-temporal synchronicity. However, little is known about the effects of ongoing brain state or preceding sleep-wake history on the nonlinear dynamics of brain activity. Recent advances in developing novel mathematical approaches for investigating temporal structure of brain activity based on such measures, as Lempel-Ziv complexity (LZC) can provide insights that go beyond those obtained with conventional techniques of signal analysis. Here, we used extensive data sets obtained in spontaneously awake and sleeping adult male laboratory rats, as well as during and after sleep deprivation, to perform a detailed analysis of cortical LFP and neuronal activity with LZC approach. We found that activated brain states-waking and rapid eye movement (REM) sleep are characterized by higher LZC compared with non-rapid eye movement (NREM) sleep. Notably, LZC values derived from the LFP were especially low during early NREM sleep after sleep deprivation and toward the middle of individual NREM sleep episodes. We conclude that LZC is an important and yet largely unexplored measure with a high potential for investigating neurophysiological mechanisms of brain activity in health and disease.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
AuthorsEmailORCID
Abásolo, DUNSPECIFIEDUNSPECIFIED
Simons, SUNSPECIFIEDUNSPECIFIED
Morgado da Silva, RUNSPECIFIEDUNSPECIFIED
Tononi, GUNSPECIFIEDUNSPECIFIED
Vyazovskiy, VVUNSPECIFIEDUNSPECIFIED
Date : April 2015
Identification Number : 10.1152/jn.00575.2014
Uncontrolled Keywords : Lempel-Ziv complexity, local field potentials, neuronal activity, rats, sleep
Related URLs :
Additional Information : Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society
Depositing User : Symplectic Elements
Date Deposited : 01 Jul 2015 14:12
Last Modified : 02 Jul 2015 01:33
URI: http://epubs.surrey.ac.uk/id/eprint/807345

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