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In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity.

Hamza, E, Akdis, CA, Wagner, B, Steinbach, F and Marti, E (2013) In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity. Clin Exp Allergy, 43 (8). pp. 889-901.

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Abstract

Insect bite hypersensitivity (IBH) is a recurrent allergic dermatitis of horses with similarities to human atopic eczema, caused by bites of insects of the genus Culicoides. Previous studies suggested a dysregulated T cell tolerance to Culicoides allergen in IBH-affected horses.

Item Type: Article
Authors :
AuthorsEmailORCID
Hamza, EUNSPECIFIEDUNSPECIFIED
Akdis, CAUNSPECIFIEDUNSPECIFIED
Wagner, BUNSPECIFIEDUNSPECIFIED
Steinbach, FUNSPECIFIEDUNSPECIFIED
Marti, EUNSPECIFIEDUNSPECIFIED
Date : August 2013
Identification Number : https://doi.org/10.1111/cea.12131
Uncontrolled Keywords : CD4+ CD25+ T cells, FoxP3, IBH, IL-10, IL-4, Icelandic horses, Treg expansion, Treg induction, Treg suppression, allergy, rIL-2 and rTGF-β1., retinoic acid and rapamycin, Allergens, Animals, Antigens, CD4, Cytokines, Epitopes, T-Lymphocyte, Female, Forkhead Transcription Factors, Horses, Hypersensitivity, Immune Tolerance, Insect Bites and Stings, Interleukin-2, Interleukin-2 Receptor alpha Subunit, Lymphocyte Activation, Male, T-Lymphocytes, Regulatory, Transforming Growth Factor beta
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 10:51
Last Modified : 28 Mar 2017 10:51
URI: http://epubs.surrey.ac.uk/id/eprint/806884

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