In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity.

Hamza, E, Akdis, CA, Wagner, B, Steinbach, F and Marti, E (2013) In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity. Clin Exp Allergy, 43 (8). pp. 889-901.

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Abstract

Insect bite hypersensitivity (IBH) is a recurrent allergic dermatitis of horses with similarities to human atopic eczema, caused by bites of insects of the genus Culicoides. Previous studies suggested a dysregulated T cell tolerance to Culicoides allergen in IBH-affected horses.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Hamza, E, Akdis, CA, Wagner, B, Steinbach, F and Marti, E
Date :	August 2013
DOI :	10.1111/cea.12131
Uncontrolled Keywords :	CD4+ CD25+ T cells, FoxP3, IBH, IL-10, IL-4, Icelandic horses, Treg expansion, Treg induction, Treg suppression, allergy, rIL-2 and rTGF-β1., retinoic acid and rapamycin, Allergens, Animals, Antigens, CD4, Cytokines, Epitopes, T-Lymphocyte, Female, Forkhead Transcription Factors, Horses, Hypersensitivity, Immune Tolerance, Insect Bites and Stings, Interleukin-2, Interleukin-2 Receptor alpha Subunit, Lymphocyte Activation, Male, T-Lymphocytes, Regulatory, Transforming Growth Factor beta
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	28 Mar 2017 10:51
Last Modified :	24 Jan 2020 12:32
URI:	http://epubs.surrey.ac.uk/id/eprint/806884

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