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Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance

Morgan, SB, Graham, SP, Sánchez Cordón, PJ, Mokhtar, H, Steinbach, F, Frossard, JP, Bodman-Smith, KB, Salguero, FJ, Rebel, JMJ and Weesendorp, E (2013) Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance Veterinary Microbiology, 163 (1-2). pp. 13-22.

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Abstract

Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases of swine worldwide. Since its first emergence in 1987 the PRRS virus (PRRSV) has become particularly divergent with highly pathogenic strains appearing in both Europe and Asia. However, the underlying mechanisms of PRRSV pathogenesis are still unclear. This study sets out to determine the differences in pathogenesis between subtype 1 and 3 strains of European PRRSV (PRRSV-I), and compare the immune responses mounted against these strains. Piglets were infected with 3 strains of PRRSV-I: Lelystad virus, 215-06 a British field strain and SU1-bel from Belarus. Post-mortem examinations were performed at 3 and 7 days post-infection (dpi), and half of the remaining animals in each group were inoculated with an Aujeszky's disease (ADV) vaccine to investigate possible immune suppression resulting from PRRSV infection. The subtype 3 SU1-bel strain displayed greater clinical signs and lung gross pathology scores compared with the subtype 1 strains. This difference did not appear to be caused by higher virus replication, as viraemia and viral load in broncho-alveolar lavage fluid (BALF) were lower in the SU1-bel group. Infection with SU1-bel induced an enhanced adaptive immune response with greater interferon (IFN)-γ responses and an earlier PRRSV-specific antibody response. Infection with PRRSV did not affect the response to vaccination against ADV. Our results indicate that the increased clinical and pathological effect of the SU1-bel strain is more likely to be caused by an enhanced inflammatory immune response rather than higher levels of virus replication. © 2012.

Item Type: Article
Authors :
AuthorsEmailORCID
Morgan, SBUNSPECIFIEDUNSPECIFIED
Graham, SPUNSPECIFIEDUNSPECIFIED
Sánchez Cordón, PJUNSPECIFIEDUNSPECIFIED
Mokhtar, HUNSPECIFIEDUNSPECIFIED
Steinbach, FUNSPECIFIEDUNSPECIFIED
Frossard, JPUNSPECIFIEDUNSPECIFIED
Bodman-Smith, KBUNSPECIFIEDUNSPECIFIED
Salguero, FJUNSPECIFIEDUNSPECIFIED
Rebel, JMJUNSPECIFIEDUNSPECIFIED
Weesendorp, EUNSPECIFIEDUNSPECIFIED
Date : 2013
Identification Number : https://doi.org/10.1016/j.vetmic.2012.11.024
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 10:51
Last Modified : 28 Mar 2017 10:51
URI: http://epubs.surrey.ac.uk/id/eprint/806876

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