University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Light-induced melatonin suppression: age-related reduction in response to short wavelength light

Herljevic, M, Middleton, Benita, Thapan, K and Skene, Debra (2005) Light-induced melatonin suppression: age-related reduction in response to short wavelength light Experimental Gerontology, 40 (3). pp. 237-242.

[img]
Preview
Text
Herljevic_ExpGeron2005.pdf - ["content_typename_UNSPECIFIED" not defined]
Available under License : See the attached licence file.

Download (208kB) | Preview
[img]
Preview
PDF (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

One of the possible causes of disturbed circadian rhythms and sleep in the elderly may be impaired photic input to the circadian clock. Age-related changes in lens density are known to reduce the transmission of short wavelength light, which has been shown to be most effective in suppressing nocturnal melatonin. The aim of the study therefore was to investigate age-related changes in melatonin suppression in response to short and medium wavelength light. Young premenopausal (n=13) and postmenopausal (n=21) women were exposed to 30 min of monochromatic light at two different wavelengths and irradiances (λmax 456 nm: 3.8 and 9.8 μW/cm2; λmax 548 nm: 28 and 62 μW/cm2). Melatonin suppression was compared across light treatments and between age groups. Significantly reduced melatonin suppression was noted in the elderly subjects following exposure to short wavelength (456 nm) light compared to the young subjects. These results are likely to reflect age-related changes in lens density.

Item Type: Article
Authors :
NameEmailORCID
Herljevic, MUNSPECIFIEDUNSPECIFIED
Middleton, BenitaB.Middleton@surrey.ac.ukUNSPECIFIED
Thapan, KUNSPECIFIEDUNSPECIFIED
Skene, DebraD.Skene@surrey.ac.ukUNSPECIFIED
Date : 2005
Identification Number : 10.1016/j.exger.2004.12.001
Depositing User : Symplectic Elements
Date Deposited : 20 Jul 2017 11:00
Last Modified : 20 Jul 2017 11:00
URI: http://epubs.surrey.ac.uk/id/eprint/806357

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800