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Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia

Hambsch, B, Otte, DM, Racz, I, Zimmer, A, Keyworth, H, Lind, J, Kitchen, I and Bailey, A (2014) Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia British Journal of Pharmacology, 171 (7). pp. 1758-1771.

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Abstract

Background and Purpose The prevalence of smoking in schizophrenia patients is exceptionally high; it is not known why but many researchers suggest that smoking constitutes a form of self-medication. Among the symptoms of schizophrenia that may be improved by nicotine are cognitive deficits. Hence, we studied the effects of long-term nicotine administration on cognition in a genetic animal model of schizophrenia susceptibility, G72-transgenic (G72Tg) mice. Experimental Approach The effect of long-term nicotine or saline, administered by osmotic minipumps, on different cognitive domains was assessed in G72Tg mice and controls using a battery of behavioural tests. To investigate the mechanism underlying phenotypic differences, quantitative autoradiographic mapping of nACh receptor subtypes was performed in forebrain structures to explore effects of chronic nicotine exposure on nACh receptor density in wild-type (WT) and G72Tg mice. Key Results Genotype significantly affected the cognitive effects of chronic nicotine administration. Whereas chronic nicotine disrupted cognitive performance in WT mice, it was effective at restoring impaired prepulse inhibition, working memory and social recognition in G72Tg mice. However, long-term spatial learning was further impaired by nicotine in transgenic animals. In contrast, associative learning was protected by G72-expression against the adverse nicotine effects seen in WT animals. G72-expression did not decisively influence nicotine-induced up-regulation of the α4β2subtype, whereas α7nACh receptor density was differentially altered by genotype or by a genotype·treatment interaction in specific brain areas, most notably hippocampal subregions. Conclusions and Implications Our data support the hypothesis that nicotine self-medication of schizophrenics improves cognitive symptoms, possibly by facilitating nicotine-induced α7nACh receptor activation in the hippocampus. © 2014 The British Pharmacological Society.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Hambsch, BUNSPECIFIEDUNSPECIFIED
Otte, DMUNSPECIFIEDUNSPECIFIED
Racz, IUNSPECIFIEDUNSPECIFIED
Zimmer, AUNSPECIFIEDUNSPECIFIED
Keyworth, HUNSPECIFIEDUNSPECIFIED
Lind, JUNSPECIFIEDUNSPECIFIED
Kitchen, IUNSPECIFIEDUNSPECIFIED
Bailey, AUNSPECIFIEDUNSPECIFIED
Date : 2014
Identification Number : 10.1111/bph.12578
Additional Information : This is the accepted version of the following article: Hambsch B, Otte DM, Racz I, Zimmer A, Keyworth H, Lind J, Kitchen I, Bailey A. (2014) Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia. British Journal of Pharmacology 171(7):1758-1771, which has been published in final form at http://dx.doi.org/10.1111/bph.12578
Depositing User : Symplectic Elements
Date Deposited : 04 Nov 2014 10:24
Last Modified : 18 Mar 2015 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/806355

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