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Neuroimaging, cognition, light and circadian rhythms.

Gaggioni, G, Maquet, P, Schmidt, C, Dijk, DJ and Vandewalle, G (2014) Neuroimaging, cognition, light and circadian rhythms. Front Syst Neurosci, 8.

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In humans, sleep and wakefulness and the associated cognitive processes are regulated through interactions between sleep homeostasis and the circadian system. Chronic disruption of sleep and circadian rhythmicity is common in our society and there is a need for a better understanding of the brain mechanisms regulating sleep, wakefulness and associated cognitive processes. This review summarizes recent investigations which provide first neural correlates of the combined influence of sleep homeostasis and circadian rhythmicity on cognitive brain activity. Markers of interindividual variations in sleep-wake regulation, such as chronotype and polymorphisms in sleep and clock genes, are associated with changes in cognitive brain responses in subcortical and cortical areas in response to manipulations of the sleep-wake cycle. This review also includes recent data showing that cognitive brain activity is regulated by light, which is a powerful modulator of cognition and alertness and also directly impacts sleep and circadian rhythmicity. The effect of light varied with age, psychiatric status, PERIOD3 genotype and changes in sleep homeostasis and circadian phase. These data provide new insights into the contribution of demographic characteristics, the sleep-wake cycle, circadian rhythmicity and light to brain functioning.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
Date : 2014
Identification Number : 10.3389/fnsys.2014.00126
Uncontrolled Keywords : circadian, cognition, fMRI, inter-individual differences in sleep-wake regulation, light, non-image-forming, non-visual, sleep
Related URLs :
Additional Information : This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.
Depositing User : Symplectic Elements
Date Deposited : 04 Nov 2014 10:50
Last Modified : 20 Dec 2014 14:37

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