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A method to assess the dissipation of residual hypnotics: Eszopiclone versus zopiclone

Boyle, J, Atzori, G, Dijk, D-J, Groeger, JA, Paska, W, Jones, S, Scott, J, Cooper, JA, Gandhi, P and Rockett, C (2012) A method to assess the dissipation of residual hypnotics: Eszopiclone versus zopiclone Journal of Clinical Psychopharmacology, 32 (5). pp. 704-709.

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Abstract

Next-day residual effects of single evening doses of 3 mg of eszopiclone, 7.5 mg of zopiclone, and placebo were assessed in a randomized, double-blind, placebo-controlled, 3-way crossover study that used a mild sleep restriction protocol (sleep duration, 7 hours). During each period, 91 healthy volunteers spent 2 consecutive nights in the laboratory with time in bed restricted to 7 hours. Volunteers completed the Continuous Tracking Test, Critical Flicker Fusion task, Digit Symbol Substitution Test, N-back tasks, and Linear Analogue Rating Scales every half-hour from 7.5 to 11.5 hours after dose, commencing 15 minutes after awakening. Nighttime dosing of both eszopiclone (3 mg) and racemic zopiclone (7.5 mg) was associated with next-day performance impairment, and these residual effects dissipated over time. Eszopiclone did not differ from zopiclone on the primary end point, mean Continuous Tracking Test tracking error averaged from 7.5 to 9.5 hours after dose; however, a prespecified post hoc parametric analysis of reciprocal-transformed data favored eszopiclone over racemic zopiclone (P = 0.026). © 2012 Lippincott Williams & Wilkins.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > Surrey Clinical Research Centre
Authors :
AuthorsEmailORCID
Boyle, JUNSPECIFIEDUNSPECIFIED
Atzori, GUNSPECIFIEDUNSPECIFIED
Dijk, D-JUNSPECIFIEDUNSPECIFIED
Groeger, JAUNSPECIFIEDUNSPECIFIED
Paska, WUNSPECIFIEDUNSPECIFIED
Jones, SUNSPECIFIEDUNSPECIFIED
Scott, JUNSPECIFIEDUNSPECIFIED
Cooper, JAUNSPECIFIEDUNSPECIFIED
Gandhi, PUNSPECIFIEDUNSPECIFIED
Rockett, CUNSPECIFIEDUNSPECIFIED
Date : October 2012
Identification Number : 10.1097/JCP.0b013e3182664eec
Additional Information : This is a non-final version of an article published in final form in the Journal of Clinical Psychopharmacology,32,5,704-709, 0271-0749. Copyright: Lippincott, Williams & Wilkins
Depositing User : Symplectic Elements
Date Deposited : 07 Nov 2014 16:00
Last Modified : 27 Jan 2015 02:33
URI: http://epubs.surrey.ac.uk/id/eprint/806293

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