University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep

Klerman, EB, Wang, W, Duffy, JF, Dijk, Derk-Jan, Czeisler, CA and Kronauer, RE (2013) Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep Neurobiology of Aging, 34 (1). pp. 309-318.

[img] Text
Survival_Analysis.pdf - Version of Record
Restricted to Repository staff only
Available under License : See the attached licence file.

Download (1MB)
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

A common complaint of older persons is disturbed sleep, typically characterized as an inability to return to sleep after waking. As every sleep episode (i.e., time in bed) includes multiple transitions between wakefulness and sleep (which can be subdivided into rapid eye movement [REM] sleep and non-REM [NREM] sleep), we applied survival analysis to sleep data to determine whether changes in the "hazard" (duration-dependent probability) of awakening from sleep and/or returning to sleep underlie age-related sleep disturbances. The hazard of awakening from sleep-specifically NREM sleep-was much greater in older than in young adults. We found, however, that when an individual had spontaneously awakened, the probability of falling back asleep was not greater in young persons. Independent of bout length, the number of transitions between NREM and REM sleep stages relative to number of transitions to wake was approximately 6 times higher in young than older persons, highlighting the difficulty in maintaining sleep in older persons. Interventions to improve age-related sleep complaints should thus target this change in awakenings. © 2013 Elsevier Inc.

Item Type: Article
Authors :
NameEmailORCID
Klerman, EBUNSPECIFIEDUNSPECIFIED
Wang, WUNSPECIFIEDUNSPECIFIED
Duffy, JFUNSPECIFIEDUNSPECIFIED
Dijk, Derk-JanD.J.Dijk@surrey.ac.ukUNSPECIFIED
Czeisler, CAUNSPECIFIEDUNSPECIFIED
Kronauer, REUNSPECIFIEDUNSPECIFIED
Date : January 2013
Identification Number : 10.1016/j.neurobiolaging.2012.05.018
Copyright Disclaimer : © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 16 Aug 2017 11:53
Last Modified : 16 Aug 2017 11:53
URI: http://epubs.surrey.ac.uk/id/eprint/806288

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800