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The direction of shift-work rotation impacts metabolic risk independent of chronotype and social jetlag - An exploratory pilot study.

Kantermann, T, Duboutay, F, Haubruge, D, Hampton, S, Darling, AL, Berry, JL, Kerkhofs, M, Boudjeltia, KZ and Skene, DJ (2014) The direction of shift-work rotation impacts metabolic risk independent of chronotype and social jetlag - An exploratory pilot study. Chronobiology International: the journal of biological and medical rhythm research. pp. 1-7.

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Abstract

The aim of this pilot study was to explore the risk of metabolic abnormalities in steel workers employed in different shift-work rotations. Male workers in a steel factory [16 employed in a fast clockwise rotation (CW), 18 in slow counterclockwise rotation (CC), 9 day workers (DW); mean age 43.3 ± SD 6.8 years] with at least 5 years experience in their current work schedule participated. All workers provided fasting blood samples between 06:00 and 08:00 h for plasma glucose, insulin, apo-lipoproteins A and B (ApoA, ApoB), high- and low-density lipoproteins (HDL and LDL), total cholesterol (tCH), triglycerides (TG), minimally oxidized (mox) LDL, C-reactive protein (CRP), interleukin-8 (IL-8) and serum 25-hydroxyvitamin D (25(OH)D). HOMA index (homeostatic model assessment) was calculated to evaluate insulin resistance, beta cell function and risk of diabetes. Information on demographics, health, stimulants, sleep, social and work life, chronotype (phase of entrainment) and social jetlag (difference between mid-sleep on workdays and free days) as a surrogate for circadian disruption was collected by questionnaire. Neither chronotype nor social jetlag was associated with any of the metabolic risk blood markers. There were no significant differences in 25(OH)D, ApoA, ApoB, CRP, HDL, IL-8, insulin, LDL, mox-LDL, mox-LDL/ApoB ratio, tCH and TG levels between the three work groups. Although we did observe absolute differences in some of these markers, the small sample size of our study population might prevent these differences being statistically significant. Fasting glucose and HOMA index were significantly lower in CW compared to DW and CC, indicating lower metabolic risk. Reasons for the lower fasting glucose and HOMA index in CW workers remains to be clarified. Future studies of workers in different shift rotations are warranted to understand better the differential effects of shift-work on individual workers and their health indices.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Kantermann, TUNSPECIFIEDUNSPECIFIED
Duboutay, FUNSPECIFIEDUNSPECIFIED
Haubruge, DUNSPECIFIEDUNSPECIFIED
Hampton, SUNSPECIFIEDUNSPECIFIED
Darling, ALUNSPECIFIEDUNSPECIFIED
Berry, JLUNSPECIFIEDUNSPECIFIED
Kerkhofs, MUNSPECIFIEDUNSPECIFIED
Boudjeltia, KZUNSPECIFIEDUNSPECIFIED
Skene, DJUNSPECIFIEDUNSPECIFIED
Date : 4 September 2014
Identification Number : 10.3109/07420528.2014.957295
Contributors :
ContributionNameEmailORCID
EditorPortaluppi, FUNSPECIFIEDUNSPECIFIED
Uncontrolled Keywords : Clockwise, Chronotype, Counterclockwise, Metabolic, Shift-work, Social-jetlag
Related URLs :
Additional Information : This is an electronic version of an article published as Kantermann T, Duboutay F, Haubruge D, Hampton S, Darling AL, Berry JL, Kerkhofs M, Boudjeltia KZ, Skene DJ (2014). The direction of shift-work rotation impacts metabolic risk independent of chronotype and social jetlag - An exploratory pilot study. Chronobiology International: the journal of biological and medical rhythm research 1-7 04. CHRONOBIOLOGY INTERNATIONAL is available online at: http://informahealthcare.com/journal/cbi
Depositing User : Symplectic Elements
Date Deposited : 15 Oct 2014 09:39
Last Modified : 04 Sep 2015 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/806137

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