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Genome-wide comparison of medieval and modern Mycobacterium leprae

Schuenemann, VJ, Bos, KI, Krause, J, Singh, P, Benjak, A, Busso, P, Cole, ST, Mendum, TA, Wu, H, Stewart, GR , Taylor, GM, Krause-Kyora, B, Nebel, A, Jäger, G, Herbig, A, Nieselt, K, Economou, C, Boldsen, JL, Kjellström, A, Bauer, P, Lee, OY-C, Wu, HHT, Minnikin, DE, Besra, GS, Tucker, K, Roffey, S and Sow, SO (2013) Genome-wide comparison of medieval and modern Mycobacterium leprae Science, 341 (6142). pp. 179-183.

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Abstract

Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons of five medieval leprosy cases from the United Kingdom, Sweden, and Denmark. In one case, the DNA was so well preserved that full de novo assembly of the ancient bacterial genome could be achieved through shotgun sequencing alone. The ancient M. leprae sequences were compared with those of 11 modern strains, representing diverse genotypes and geographic origins. The comparisons revealed remarkable genomic conservation during the past 1000 years, a European origin for leprosy in the Americas, and the presence of an M. leprae genotype in medieval Europe now commonly associated with the Middle East. The exceptional preservation of M. leprae biomarkers, both DNA and mycolic acids, in ancient skeletons has major implications for palaeomicrobiology and human pathogen evolution.

Item Type: Article
Authors :
NameEmailORCID
Schuenemann, VJUNSPECIFIEDUNSPECIFIED
Bos, KIUNSPECIFIEDUNSPECIFIED
Krause, JUNSPECIFIEDUNSPECIFIED
Singh, PUNSPECIFIEDUNSPECIFIED
Benjak, AUNSPECIFIEDUNSPECIFIED
Busso, PUNSPECIFIEDUNSPECIFIED
Cole, STUNSPECIFIEDUNSPECIFIED
Mendum, TAUNSPECIFIEDUNSPECIFIED
Wu, HUNSPECIFIEDUNSPECIFIED
Stewart, GRUNSPECIFIEDUNSPECIFIED
Taylor, GMUNSPECIFIEDUNSPECIFIED
Krause-Kyora, BUNSPECIFIEDUNSPECIFIED
Nebel, AUNSPECIFIEDUNSPECIFIED
Jäger, GUNSPECIFIEDUNSPECIFIED
Herbig, AUNSPECIFIEDUNSPECIFIED
Nieselt, KUNSPECIFIEDUNSPECIFIED
Economou, CUNSPECIFIEDUNSPECIFIED
Boldsen, JLUNSPECIFIEDUNSPECIFIED
Kjellström, AUNSPECIFIEDUNSPECIFIED
Bauer, PUNSPECIFIEDUNSPECIFIED
Lee, OY-CUNSPECIFIEDUNSPECIFIED
Wu, HHTUNSPECIFIEDUNSPECIFIED
Minnikin, DEUNSPECIFIEDUNSPECIFIED
Besra, GSUNSPECIFIEDUNSPECIFIED
Tucker, KUNSPECIFIEDUNSPECIFIED
Roffey, SUNSPECIFIEDUNSPECIFIED
Sow, SOUNSPECIFIEDUNSPECIFIED
Date : 2013
Identification Number : 10.1126/science.1238286
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 13:11
Last Modified : 31 Oct 2017 16:56
URI: http://epubs.surrey.ac.uk/id/eprint/806014

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