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Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays.

Barazzuol, L, Jeynes, JC, Merchant, MJ, Wéra, AC, Barry, MA, Kirkby, KJ and Suzuki, M (2015) Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays. Int J Radiat Biol, 91 (1). pp. 90-98.

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Abstract

Prognosis for patients with glioblastoma (GBM) remains poor, and new treatments are needed. Here we used a combination of two novel treatment modalities: Carbon ions and a histone deacetylase inhibitor (HDACi). We compared these to conventional X-rays, measuring the increased effectiveness of carbon ions as well as radiosensitization using HDACi.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
AuthorsEmailORCID
Barazzuol, LUNSPECIFIEDUNSPECIFIED
Jeynes, JCUNSPECIFIEDUNSPECIFIED
Merchant, MJUNSPECIFIEDUNSPECIFIED
Wéra, ACUNSPECIFIEDUNSPECIFIED
Barry, MAUNSPECIFIEDUNSPECIFIED
Kirkby, KJUNSPECIFIEDUNSPECIFIED
Suzuki, MUNSPECIFIEDUNSPECIFIED
Date : January 2015
Identification Number : 10.3109/09553002.2014.946111
Uncontrolled Keywords : DNA double-strand break repair, High-LET, chromatin decondensation, clonogenic assay, Carbon, Cell Line, Tumor, DNA, DNA Repair, Glioblastoma, Histone Deacetylase Inhibitors, Histones, Humans, Hydroxamic Acids, Radiation-Sensitizing Agents, X-Rays
Related URLs :
Additional Information : This is an electronic version of an article published in International Journal of Radiation Biology, Ahead of Print : Pages 1-19 Radiosensitisation of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays. L. Barazzuol , J.C.G Jeynes , M.J. Merchant , A-C. Wéra , M. Barry , K.J. Kirkby , M. Suzuki (doi:10.3109/09553002.2014.946111). Int J Radiat Biol is available online at http://informahealthcare.com/journal/rab
Depositing User : Symplectic Elements
Date Deposited : 09 Sep 2014 11:22
Last Modified : 21 Jul 2015 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/805893

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