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Vitamin D deficiency in UK South Asian Women of childbearing age: A comparative longitudinal investigation with UK Caucasian women

Darling, AL, Hart, KH, Lanham-New, SA, MacDonald, HM, Horton, K, Kang'Ombe, AR and Berry, JL (2013) Vitamin D deficiency in UK South Asian Women of childbearing age: A comparative longitudinal investigation with UK Caucasian women Osteoporosis International, 24 (2). pp. 477-488.

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Abstract

This is the first 1-year longitudinal study which assesses vitamin D deficiency in young UK-dwelling South Asian women. The findings are that vitamin D deficiency is extremely common in this group of women and that it persists all year around, representing a significant public health concern. Introduction: There is a lack of longitudinal data assessing seasonal variation in vitamin D status in young South Asian women living in northern latitudes. Studies of postmenopausal South Asian women suggest a lack of seasonal change in 25-hydroxy vitamin D [25(OH)D], although it is unclear whether this is prevalent among premenopausal South Asians. We aimed to evaluate, longitudinally, seasonal changes in 25(OH)D and prevalence of vitamin D deficiency in young UK-dwelling South Asian women as compared with Caucasians. We also aimed to establish the relative contributions of dietary vitamin D and sun exposure in explaining serum 25(OH)D. Methods: This is a 1-year prospective cohort study assessing South Asian (n = 35) and Caucasian (n = 105) premenopausal women living in Surrey, UK (51 N), aged 20-55 years. The main outcome measured was serum 25(OH)D concentration. Secondary outcomes were serum parathyroid hormone, self-reported dietary vitamin D intake and UVB exposure by personal dosimetry. Results: Serum 25(OH)D <25 nmol/L was highly prevalent in South Asians in the winter (81 %) and autumn (79.2 %). Deficient status (below 50 nmol/L) was common in Caucasian women. Multi-level modelling suggested that, in comparison to sun exposure (1.59, 95 %CI = 0.83-2.35), dietary intake of vitamin D had no impact on 25(OH)D levels (-0.08, 95 %CI = -1.39 to 1.23). Conclusions: Year-round vitamin D deficiency was extremely common in South Asian women. These findings pose great health threats regarding the adverse effects of vitamin D deficiency in pregnancy and warrant urgent vitamin D public health policy and action. © 2012 International Osteoporosis Foundation and National Osteoporosis Foundation.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Darling, ALUNSPECIFIEDUNSPECIFIED
Hart, KHUNSPECIFIEDUNSPECIFIED
Lanham-New, SAUNSPECIFIEDUNSPECIFIED
MacDonald, HMUNSPECIFIEDUNSPECIFIED
Horton, KUNSPECIFIEDUNSPECIFIED
Kang'Ombe, ARUNSPECIFIEDUNSPECIFIED
Berry, JLUNSPECIFIEDUNSPECIFIED
Date : February 2013
Identification Number : 10.1007/s00198-012-1973-2
Additional Information : The original publication is available at http://www.springerlink.com
Depositing User : Symplectic Elements
Date Deposited : 09 Sep 2014 08:19
Last Modified : 13 Sep 2014 01:37
URI: http://epubs.surrey.ac.uk/id/eprint/805891

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