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Corticospinal Tract Integrity and Lesion Volume Play Different Roles in Chronic Hemiparesis and Its Improvement Through Motor Practice

Sterr, A, Dean, PJA, Szameitat, AJ, Conforto, AB and Shen, S (2013) Corticospinal Tract Integrity and Lesion Volume Play Different Roles in Chronic Hemiparesis and Its Improvement Through Motor Practice Neurorehabil Neural Repair, 28 (4). pp. 335-343.

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Corticospinal tract integrity and lesion voulme play different roles in chronic hemiparesis and its improvement through motor practice.pdf - ["content_typename_Published version (Publisher's proof or final PDF)" not defined]
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Abstract

Background. Initial evidence suggests that the integrity of the ipsilesional corticospinal tract (CST) after stroke is strongly related to motor function in the chronic state but not the treatment gain induced by motor rehabilitation. Objective. We examined the association of motor status and treatment benefit by testing patients with a wide range of severity of hemiparesis of the left and right upper extremity. Method. Diffusion tensor imaging was performed in 22 patients beyond 12 months after onset of stroke with severe to moderate hemiparesis. Motor function was tested before and after 2 weeks of modified constraint-induced movement therapy. Results. CST integrity, but not lesion volume, correlated with the motor ability measures of the Wolf Motor Function Test and the Motor Activity Log. No differences were found between left and right hemiparesis. Motor performance improved significantly with the treatment regime, and did so equally for patients with left and right arm paresis. However, treatment benefit was not associated with either CST integrity or lesion volume. Conclusion. CST integrity correlated best in this small trial with chronic long-term status but not treatment-induced improvements. The CST may play a different role in the mechanisms mediating long-term outcome compared to those underlying practice-induced gains after a chronic plateau in motor function.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
AuthorsEmailORCID
Sterr, AUNSPECIFIEDUNSPECIFIED
Dean, PJAUNSPECIFIEDUNSPECIFIED
Szameitat, AJUNSPECIFIEDUNSPECIFIED
Conforto, ABUNSPECIFIEDUNSPECIFIED
Shen, SUNSPECIFIEDUNSPECIFIED
Date : 11 December 2013
Identification Number : 10.1177/1545968313510972
Related URLs :
Additional Information : This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).
Depositing User : Symplectic Elements
Date Deposited : 29 May 2014 16:21
Last Modified : 13 Aug 2014 01:33
URI: http://epubs.surrey.ac.uk/id/eprint/805594

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