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Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

Jeynes, JCG, Jeynes, C, Merchant, MJ and Kirkby, KJ (2013) Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles Analyst (138). pp. 7070-7074.

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Abstract

The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mass and GNP rate of uptake. This was true for GNPs non-specifically bound to fetal bovine serum or conjugated to a cell penetrating peptide. Within a population of cells, GNP content varied naturally by a factor greater than 10 between individual cells.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
AuthorsEmailORCID
Jeynes, JCGUNSPECIFIEDUNSPECIFIED
Jeynes, CUNSPECIFIEDUNSPECIFIED
Merchant, MJUNSPECIFIEDUNSPECIFIED
Kirkby, KJUNSPECIFIEDUNSPECIFIED
Date : 26 September 2013
Identification Number : 10.1039/C3AN01406A
Uncontrolled Keywords : gold nanoparticles, endocytosis, oog normal distributions, ion beam analysis, mote carlo simulation, cancer cells
Additional Information : This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Depositing User : Symplectic Elements
Date Deposited : 29 May 2014 15:45
Last Modified : 09 Jun 2014 13:42
URI: http://epubs.surrey.ac.uk/id/eprint/805589

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