Elastic atlas registration of β- autoradiograms using scattered data interpolators

Cabello, J, Wells, K, Metaxas, A, Bailey, A and Kitchen, I (2009) Elastic atlas registration of β- autoradiograms using scattered data interpolators In: Nuclear Science Symposium Conference Record (NSS/MIC), 2009, 2009-10-24 - 2009-11-01, Orlando, Florida.

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Abstract

Autoradiography is a widely extended pre-clinical nuclear imaging modality used in life sciences to investigate and localise radiolabelled biological pathways in thin ex-vivo tissue sections. After the tissue section has been exposed to an ionising radiation detector the resulting labelled regions are subsequently analysed. Typically, the resulting autoradiograms are analysed manually by an expert life scientists using a visual template as reference to measure the different radioligand uptake levels in the different areas of, in our case, mouse brain. This process is extremely time consuming and error prone, with the expertise of the life scientist playing a significant role. In this paper we describe a semi-automatic method to register a template brain atlas on to the brain autoradiogram making the analysis process more efficient, repeatable and independent of the expertise of the life scientist. The method first identifies those regions with high and low level of radioligand uptake by region growing segmentation. Subsequently, the counterpart regions in the corresponding atlas image are manually identified. Finally a set of control points is extracted from each region contour in the autoradiogram and the atlas image to apply a scattered data interpolator. ©2009 IEEE.

Item Type:	Conference or Workshop Item (Conference Paper)
Divisions :	Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :	Name Email ORCID Cabello, J Wells, K Metaxas, A Bailey, A Kitchen, I
Date :	2009
DOI :	10.1109/NSSMIC.2009.5401863
Contributors :	Contribution Name Email ORCID http://www.loc.gov/loc.terms/relators/PBL IEEE,
Additional Information :	© 2009 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Depositing User :	Symplectic Elements
Date Deposited :	01 Apr 2014 14:26
Last Modified :	31 Oct 2017 16:38
URI:	http://epubs.surrey.ac.uk/id/eprint/805200

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