QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells.
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Fisher, CP, Plant, NJ, Moore, JB and Kierzek, AM (2013) QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells. Bioinformatics, 29 (24). pp. 3181-3190.
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Official URL: http://dx.doi.org/10.1093/bioinformatics/btt552
Abstract
Dynamic simulation of genome-scale molecular interaction networks will enable the mechanistic prediction of genotype-phenotype relationships. Despite advances in quantitative biology, full parameterization of whole-cell models is not yet possible. Simulation methods capable of using available qualitative data are required to develop dynamic whole-cell models through an iterative process of modelling and experimental validation.
| Item Type: | Article | |||||||||||||||
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| Divisions : | Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences | |||||||||||||||
| Authors : |
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| Date : | 15 December 2013 | |||||||||||||||
| Identification Number : | https://doi.org/10.1093/bioinformatics/btt552 | |||||||||||||||
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| Additional Information : | Copyright The Author 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||
| Depositing User : | Symplectic Elements | |||||||||||||||
| Date Deposited : | 17 Jan 2014 14:46 | |||||||||||||||
| Last Modified : | 09 Jun 2014 13:51 | |||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/804824 |
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