QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells.

Fisher, CP, Plant, NJ, Moore, JB and Kierzek, AM (2013) QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells. Bioinformatics, 29 (24). pp. 3181-3190.

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Abstract

Dynamic simulation of genome-scale molecular interaction networks will enable the mechanistic prediction of genotype-phenotype relationships. Despite advances in quantitative biology, full parameterization of whole-cell models is not yet possible. Simulation methods capable of using available qualitative data are required to develop dynamic whole-cell models through an iterative process of modelling and experimental validation.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :	Name Email ORCID Fisher, CP Plant, NJ Moore, JB Kierzek, AM
Date :	15 December 2013
DOI :	10.1093/bioinformatics/btt552
Related URLs :	Author
Additional Information :	Copyright The Author 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Depositing User :	Symplectic Elements
Date Deposited :	17 Jan 2014 14:46
Last Modified :	09 Jun 2014 13:51
URI:	http://epubs.surrey.ac.uk/id/eprint/804824

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