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Digital autoradiography using room temperature CCD and CMOS imaging technology.

Cabello, J, Bailey, A, Kitchen, I, Prydderch, M, Clark, A, Turchetta, R and Wells, K (2007) Digital autoradiography using room temperature CCD and CMOS imaging technology. Physics in Medicine and Biology, 52 (16). pp. 4993-5011.

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Abstract

CCD (charged coupled device) and CMOS imaging technologies can be applied to thin tissue autoradiography as potential imaging alternatives to using conventional film. In this work, we compare two particular devices: a CCD operating in slow scan mode and a CMOS-based active pixel sensor, operating at near video rates. Both imaging sensors have been operated at room temperature using direct irradiation with images produced from calibrated microscales and radiolabelled tissue samples. We also compare these digital image sensor technologies with the use of conventional film. We show comparative results obtained with (14)C calibrated microscales and (35)S radiolabelled tissue sections. We also present the first results of (3)H images produced under direct irradiation of a CCD sensor operating at room temperature. Compared to film, silicon-based imaging technologies exhibit enhanced sensitivity, dynamic range and linearity.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Centre for Vision Speech and Signal Processing
Authors :
AuthorsEmailORCID
Cabello, JUNSPECIFIEDUNSPECIFIED
Bailey, AUNSPECIFIEDUNSPECIFIED
Kitchen, IUNSPECIFIEDUNSPECIFIED
Prydderch, MUNSPECIFIEDUNSPECIFIED
Clark, AUNSPECIFIEDUNSPECIFIED
Turchetta, RUNSPECIFIEDUNSPECIFIED
Wells, KUNSPECIFIEDUNSPECIFIED
Date : 21 August 2007
Identification Number : 10.1088/0031-9155/52/16/019
Uncontrolled Keywords : Autoradiography, Equipment Design, Equipment Failure Analysis, Radiation Dosage, Radiographic Image Enhancement, Radiometry, Reproducibility of Results, Semiconductors, Sensitivity and Specificity, Temperature, Transducers
Related URLs :
Additional Information : Copyright 2007 Institute of Physics. This is the author's accepted manuscript.
Depositing User : Symplectic Elements
Date Deposited : 17 Jan 2014 12:19
Last Modified : 09 Jun 2014 13:50
URI: http://epubs.surrey.ac.uk/id/eprint/804818

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