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Monitoring long-term effects of mild traumatic brain injury with magnetic resonance spectroscopy: a pilot study.

Dean, PJ, Otaduy, MC, Harris, LM, McNamara, A, Seiss, E and Sterr, A (2013) Monitoring long-term effects of mild traumatic brain injury with magnetic resonance spectroscopy: a pilot study. Neuroreport, 24 (12). pp. 677-681.

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Abstract

This pilot study explores the metabolic changes associated with persistent postconcussion syndrome (PCS) after mild traumatic brain injury (mTBI; >12 months after injury) using magnetic resonance spectroscopy. We hypothesized that those mTBI participants with PCS will have larger metabolic differences than those without. Data were collected from mTBI participants with PCS, mTBI participants without PCS and non-head-injured participants (all groups: n=8). Magnetic resonance spectroscopy metabolite profiles within the dorsolateral prefrontal cortex showed a reduced creatine/choline ratio in mTBI patients compared with control participants. This data provides initial evidence for residual metabolic changes in chronic mTBI patients, but there was no conclusive relationship between these metabolic changes and PCS symptom report. Creatine is involved in maintaining energy levels in cells with high or fluctuating energy demand, suggesting that there may be some residual energy impairment in chronic mTBI.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
AuthorsEmailORCID
Dean, PJUNSPECIFIEDUNSPECIFIED
Otaduy, MCUNSPECIFIEDUNSPECIFIED
Harris, LMUNSPECIFIEDUNSPECIFIED
McNamara, AUNSPECIFIEDUNSPECIFIED
Seiss, EUNSPECIFIEDUNSPECIFIED
Sterr, AUNSPECIFIEDUNSPECIFIED
Date : 21 August 2013
Identification Number : 10.1097/WNR.0b013e3283637aa4
Related URLs :
Additional Information : This is a non-final version of an article published in final form in Neuroreport 24,(12) 2013. DOI: 10.1097/WNR.0b013e3283637aa4
Depositing User : Symplectic Elements
Date Deposited : 29 Oct 2014 15:16
Last Modified : 07 Nov 2014 14:33
URI: http://epubs.surrey.ac.uk/id/eprint/804665

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