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The effect of elevated blood sugar levels on encoding and retrieval in averbal memory task

Seiss, E, Hope, C, Guinn, A, Dean, PJA and Sterr, A (2013) The effect of elevated blood sugar levels on encoding and retrieval in averbal memory task In: 53rd Annual Meeting of the Society-for-Psychophysiological-Research, 2013-10-02 - 2013-10-06, Florence, Italy.

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Abstract

Previous studies suggest that oral glucose administration directly facilitates declarative memory encoding and retrieval (Sünram-Lea et al., 2002; Manning et al., 1992). However, glucose could indirectly facilitate memory encoding by already enhancing pre-mnemonic sensory or lexical/semantic processes, which produce important substrates for memory encoding. In the present study we used ERP measures combined with a robust placebo-controlled double-blind glucose elevation protocol to (1) replicate the glucose facilitation effect on declarative memory performance, and (2) determine whether glucose modulates pre-mnemonic or mnemonic processes at the encoding and retrieval stage. EEG was collected from 32 electrodes while participants performed a word recognition task under conditions of elevated (6.5 ± 0.12 mmol) and normal (4.57 ± 0.12 mmol) blood glucose levels. In line with the literature, recall rates were better in the glucose condition. Glucose also enlarged the LPC component, which is functionally linked to memory encoding and consolidation processes. Glucose also modulated VEPs (P1, N1), the P300, and the N400, a marker of pre-mnemonic lexical/semantic processing. The N400 amplitude positively correlated with memory performance. At the recognition stage similar effects on VEPs and the P300 were observed, and glucose numerically enhanced the FN400, while reducing the LP. In summary the glucose facilitation of declarative memory may be enacted through effects on earlier information processing stages as well as later memory-specific processes.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Divisions : Faculty of Arts and Social Sciences
Authors :
AuthorsEmailORCID
Seiss, EUNSPECIFIEDUNSPECIFIED
Hope, CUNSPECIFIEDUNSPECIFIED
Guinn, AUNSPECIFIEDUNSPECIFIED
Dean, PJAUNSPECIFIEDUNSPECIFIED
Sterr, AUNSPECIFIEDUNSPECIFIED
Date : 1 September 2013
Identification Number : https://doi.org/10.1111/psyp.12120
Contributors :
ContributionNameEmailORCID
PublisherWiley-Blackwell, UNSPECIFIEDUNSPECIFIED
Uncontrolled Keywords : Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Biological, Neurosciences, Physiology, Psychology, Psychology, Experimental, Neurosciences & Neurology, EEG, Glucose, Memory
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 15:52
Last Modified : 28 Mar 2017 15:52
URI: http://epubs.surrey.ac.uk/id/eprint/804556

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