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Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease.

Pugh, CJ, Cuthbertson, DJ, Sprung, VS, Kemp, GJ, Richardson, P, Margot Umpleby, A, Green, DJ, Timothy Cable, N and Jones, H (2013) Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease. Am J Physiol Endocrinol Metab, 305 (1). E50-E58.

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Abstract

The leading causes of mortality in nonalcoholic fatty liver disease (NAFLD) relate to cardiovascular disease (CVD). The contribution of nitric oxide (NO) to endothelial function, a surrogate of CVD risk, is currently unknown in NAFLD. We hypothesize that NO-mediated cutaneous microvessel function would be impaired in NAFLD compared with controls and that exercise would enhance microvessel function compared with conventional care. Thirteen NAFLD patients (aged 50 ± 3 yr, BMI 31 ± 1 kg/m(2)) and seven controls (48 ± 4 yr, 30 ± 2 kg/m(2)) were studied. NAFLD patients were randomized to either 16 wk of exercise or conventional care. Cutaneous microvessel function was examined using laser Doppler flowmetry combined with intradermal microdialysis of N(G)-monomethyl-l-arginine to assay the NO dilator response to local forearm heating. Magnetic resonance imaging and spectroscopy quantified abdominal and liver fat, respectively, and cardiorespiratory fitness was assessed. Differences in NO contribution to cutaneous blood flow between NAFLD and control individuals and between interventions were analyzed using general linear modeling. NO contribution to cutaneous blood flow was similar between NAFLD and controls (P = 0.47). Cardiorespiratory fitness was greater following exercise training compared with conventional care. NO contribution to cutaneous blood flow in response to heating at 42°C was 20.4% CVCmax (95% CI = 4.4, 36.4) greater following exercise training compared with conventional care (P = 0.02). Exercise training improves cutaneous microvascular NO function in NAFLD patients. The benefit of exercise training compared with conventional care strongly supports a role for exercise in the prevention of CVD in NAFLD.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Pugh, CJUNSPECIFIEDUNSPECIFIED
Cuthbertson, DJUNSPECIFIEDUNSPECIFIED
Sprung, VSUNSPECIFIEDUNSPECIFIED
Kemp, GJUNSPECIFIEDUNSPECIFIED
Richardson, PUNSPECIFIEDUNSPECIFIED
Margot Umpleby, AUNSPECIFIEDUNSPECIFIED
Green, DJUNSPECIFIEDUNSPECIFIED
Timothy Cable, NUNSPECIFIEDUNSPECIFIED
Jones, HUNSPECIFIEDUNSPECIFIED
Date : July 2013
Identification Number : 10.1152/ajpendo.00055.2013
Uncontrolled Keywords : cutaneous microvessel function, exercise, exercise training, microvascular function, nitric oxide, nonalcoholic fatty liver disease
Related URLs :
Additional Information : This article is open access on the American Journal of Physiology Website: http://ajpendo.physiology.org/content/305/1/E50
Depositing User : Symplectic Elements
Date Deposited : 23 Oct 2013 11:54
Last Modified : 08 Nov 2013 12:31
URI: http://epubs.surrey.ac.uk/id/eprint/804295

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