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The effects of antidepressants in Parkinson's disease: A meta-analysis

Frisina, PG, Tenenbaum, HR, Borod, JC and Foldi, NS (2008) The effects of antidepressants in Parkinson's disease: A meta-analysis International Journal of Neuroscience, 118 (5). pp. 667-682.

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Abstract

This study explored the therapeutic effect of antidepressants in Parkinson's disease (PD) using a meta-analysis. Altogether, 24 placebo-controlled trials qualified for inclusion and revealed that tricyclic antidepressants (TCAs) had a greater antidepressant effect relative to selective serotonin reuptake inhibitors (SSRIs), Qb(1) = 8.87, p <.01, and the mono-amine-oxidase inhibitor, selegiline, Qb(1) = 7.90, p <.01. Whereas TCAs produced a significant side effect profile (odds ratio = 3.07), adverse events were negligible with SSRIs (odds ratio = 1.83) and selegeline (odds ratio = 1.63). Antidepressants can be beneficial for patients with PD. However, the choice of antidepressants needs to take depressive symptomatologies into account while monitoring side effects. Copyright © 2008 Informa Healthcare USA, Inc.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
AuthorsEmailORCID
Frisina, PGUNSPECIFIEDUNSPECIFIED
Tenenbaum, HRUNSPECIFIEDUNSPECIFIED
Borod, JCUNSPECIFIEDUNSPECIFIED
Foldi, NSUNSPECIFIEDUNSPECIFIED
Date : May 2008
Identification Number : 10.1080/00207450701239418
Related URLs :
Additional Information : This is an electronic version of an article published as Pasquale G. Frisina, Harriet R. Tenenbaum, Joan C. Borod, and Nancy S. Foldi, (2008)The effects of antidepressants in Parkinson's disease: A meta-analysis. International Journal of Neuroscience, 118 (5)doi:10.1080/00207450701239418. International Journal of Neuroscience is available online at: http://informahealthcare.com/journal/nes
Depositing User : Symplectic Elements
Date Deposited : 28 Oct 2014 16:48
Last Modified : 03 Jan 2015 14:34
URI: http://epubs.surrey.ac.uk/id/eprint/804113

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