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C autoradiography with a novel wafer scale CMOS Active Pixel Sensor

Esposito, M, Wells, K, Anaxagoras, T, Allinson, NM and Larner, J (2013) C autoradiography with a novel wafer scale CMOS Active Pixel Sensor Journal of Instrumentation, 8 (1).

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C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution due to its fine granularity but at the same time has some limiting drawbacks such as poor linearity and rapid saturation. In recent years several digital detectors have been developed, following the technological transition from analog to digital-based detection systems in the medical and biological field. Even so such digital systems have been greatly limited by the size of their active area (a few square centimeters), which have made them unsuitable for routine use in many biological applications where sample areas are typically ∼ 10-100 cm. The Multidimensional Integrated Intelligent Imaging (MI3-Plus) consortium has recently developed a new large area CMOS Active Pixel Sensor (12.8 cm × 13.1 cm). This detector, based on the use of two different pixel resolutions, is capable of providing simultaneously low noise and high dynamic range on a wafer scale. In this paper we will demonstrate the suitability of this detector for routine beta autoradiography in a comparative approach with widely used film emulsion. © 2012 IOP Publishing Ltd and Sissa Medialab srl.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
Esposito, M
Wells, K
Anaxagoras, T
Allinson, NM
Larner, J
Date : January 2013
DOI : 10.1088/1748-0221/8/01/C01011
Additional Information : Copyright 2013 Institute of Physics. This is the author's accepted manuscript.
Depositing User : Symplectic Elements
Date Deposited : 14 Oct 2013 08:47
Last Modified : 09 Jun 2014 13:50

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