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Simulation and assessment of realistic breast lesions using fractal growth models.

Rashidnasab, A, Elangovan, P, Yip, M, Diaz, O, Dance, DR, Young, KC and Wells, K (2013) Simulation and assessment of realistic breast lesions using fractal growth models. Phys Med Biol, 58 (16). pp. 5613-5627.

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A new method of generating realistic three dimensional simulated breast lesions known as diffusion limited aggregation (DLA) is presented, and compared with the random walk (RW) method. Both methods of lesion simulation utilize a physics-based method for inserting these simulated lesions into 2D clinical mammogram images that takes into account the polychromatic x-ray spectrum, local glandularity and scatter. DLA and RW masses were assessed for realism via a receiver operating characteristic (ROC) study with nine observers. The study comprised 150 images of which 50 were real pathology proven mammograms, 50 were normal mammograms with RW inserted masses and 50 were normal mammograms with DLA inserted masses. The average area under the ROC curve for the DLA method was 0.55 (95% confidence interval 0.51-0.59) compared to 0.60 (95% confidence interval 0.56-0.63) for the RW method. The observer study results suggest that the DLA method produced more realistic masses with more variability in shape compared to the RW method. DLA generated lesions can overcome the lack of complexity in structure and shape in many current methods of mass simulation.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Centre for Vision Speech and Signal Processing
Authors :
Rashidnasab, A
Elangovan, P
Yip, M
Diaz, O
Dance, DR
Young, KC
Wells, K
Date : 21 August 2013
DOI : 10.1088/0031-9155/58/16/5613
Related URLs :
Additional Information : Copyright 2013 Institute of Physics. This is the author's accepted manuscript.
Depositing User : Symplectic Elements
Date Deposited : 01 Oct 2013 08:26
Last Modified : 21 Aug 2014 01:08

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