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First results on cell irradiation with laser-driven protons on the TARANIS system

Kar, S, Doria, D, Kakolee, KF, Prasad, R, Litt, S, Ahmed, H, Nersisyan, G, Lewis, C, Zepf, M, Borghesi, M, Schettino, G, Prise, KM, Fiorini, F, Kirby, D, Green, S, Jeynes, JCG, Merchant, MJ and Kirkby, KJ (2013) First results on cell irradiation with laser-driven protons on the TARANIS system AIP Conference Proceedings, 1546. pp. 87-89.

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Abstract

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. © 2013 AIP Publishing LLC.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
AuthorsEmailORCID
Kar, SUNSPECIFIEDUNSPECIFIED
Doria, DUNSPECIFIEDUNSPECIFIED
Kakolee, KFUNSPECIFIEDUNSPECIFIED
Prasad, RUNSPECIFIEDUNSPECIFIED
Litt, SUNSPECIFIEDUNSPECIFIED
Ahmed, HUNSPECIFIEDUNSPECIFIED
Nersisyan, GUNSPECIFIEDUNSPECIFIED
Lewis, CUNSPECIFIEDUNSPECIFIED
Zepf, MUNSPECIFIEDUNSPECIFIED
Borghesi, MUNSPECIFIEDUNSPECIFIED
Schettino, GUNSPECIFIEDUNSPECIFIED
Prise, KMUNSPECIFIEDUNSPECIFIED
Fiorini, FUNSPECIFIEDUNSPECIFIED
Kirby, DUNSPECIFIEDUNSPECIFIED
Green, SUNSPECIFIEDUNSPECIFIED
Jeynes, JCGUNSPECIFIEDUNSPECIFIED
Merchant, MJUNSPECIFIEDUNSPECIFIED
Kirkby, KJUNSPECIFIEDUNSPECIFIED
Date : 2013
Identification Number : 10.1063/1.4816612
Additional Information :

Copyright 2013 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

The following article appeared in AIP Conference Proceedings, Vol 1546 and may be found at http://dx.doi.org/10.1063/1.4816612

Depositing User : Symplectic Elements
Date Deposited : 11 Sep 2013 11:49
Last Modified : 13 Sep 2013 01:33
URI: http://epubs.surrey.ac.uk/id/eprint/799468

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