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Heat shock protein 27: its potential role in vascular disease.

Ferns, G, Shams, S and Shafi, S (2006) Heat shock protein 27: its potential role in vascular disease. Int J Exp Pathol, 87 (4). pp. 253-274.

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Heat shock proteins are molecular chaperones that have an ability to protect proteins from damage induced by environmental factors such as free radicals, heat, ischaemia and toxins, allowing denatured proteins to adopt their native configuration. Heat shock protein-27 (Hsp27) is a member of the small Hsp (sHsp) family of proteins, and has a molecular weight of approximately 27 KDa. In addition to its role as a chaperone, it has also been reported to have many additional functions. These include effects on the apoptotic pathway, cell movement and embryogenesis. In this review, we have focused on its possible role in vascular disease.

Item Type: Article
Divisions : Surrey research (other units)
Authors : Ferns, G, Shams, S and Shafi, S
Date : August 2006
DOI : 10.1111/j.1365-2613.2006.00484.x
Uncontrolled Keywords : Animals, Apoptosis, Endothelial Cells, Endothelium, Vascular, Heat-Shock Proteins, Humans, Inflammation, Models, Animal, Molecular Chaperones, Neoplasms, Protein Isoforms, Protein Processing, Post-Translational, Signal Transduction, Vascular Diseases
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 15:28
Last Modified : 24 Jan 2020 12:06

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