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Rapid detection of fibrinogen and fibrin degradation products by latex piezoelectric immunoassay

Aizawa, H, Tozuka, M, Park, J-W, Noda, K, Kurosawa, S, Kobayashi, K and Medapati Reddy, S (2003) Rapid detection of fibrinogen and fibrin degradation products by latex piezoelectric immunoassay Proceedings of the Annual IEEE International Frequency Control Symposium. pp. 961-963.

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Abstract

It was developed a conventional immunosensor for fibrinogen and fibrin degradation products (FDP) to combine a quartz crystal microbalance (QCM) with the agglutination reaction of immunized latex beads. We successfully measured FDP concentration of in human serum within 10 min by QCM method. The detection range of QCM immunosensor is covered with screening concentration of FDP in serum (less than 10 μg/ml of FDP). The time course of latex agglutination obtained from QCM immunosensor is synchronized to that of latex photometric immunoassay. Frequency shift on immunoreaction explains the increased adsorption amount of agglutinated latex on QCM.

Item Type: Article
Authors :
AuthorsEmailORCID
Aizawa, HUNSPECIFIEDUNSPECIFIED
Tozuka, MUNSPECIFIEDUNSPECIFIED
Park, J-WUNSPECIFIEDUNSPECIFIED
Noda, KUNSPECIFIEDUNSPECIFIED
Kurosawa, SUNSPECIFIEDUNSPECIFIED
Kobayashi, KUNSPECIFIEDUNSPECIFIED
Medapati Reddy, SUNSPECIFIEDUNSPECIFIED
Date : 2003
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 13:53
Last Modified : 28 Mar 2017 13:53
URI: http://epubs.surrey.ac.uk/id/eprint/796978

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