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Synthesis of beaded poly(vinyl ether) solid supports with unique solvent compatibility

Greenland, BW, Liu, S, Cavalli, Gabriel, Alpay, Esat and Steinke, JHG (2010) Synthesis of beaded poly(vinyl ether) solid supports with unique solvent compatibility Polymer, 51 (14). pp. 2984-2992.

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Abstract

Poly(vinyl ether) gels SLURPS (Superior Liquid Uptake Resin for Polymer-supported synthesis) with low cross-linking levels have been synthesized for the first time in beaded form using a non-aqueous inverse suspension polymerisation approach. The synthetic protocol was optimized with regards to several parameters including reactions conditions, type and concentration of suspension stabilizer and controlled low temperature addition of co-initiator. Particle size measurements confirm the production of beads with average diameters of 700e950 mm. Optimization of the monomer composition of the poly (vinyl ether) gels resulted in a novel beaded polymer support with considerably improved as well as unique swelling characteristics in solvents ranging from hexane to water. The synthetic utility of the new gel was confirmed by carrying out a set of transformations with complete conversion leading to a useful amino and hydroxy terminated solid-phase precursor resin. Reaction progress could be monitored easily by 1 H and 13C gel-phase NMR

Item Type: Article
Authors :
NameEmailORCID
Greenland, BWUNSPECIFIEDUNSPECIFIED
Liu, SUNSPECIFIEDUNSPECIFIED
Cavalli, GabrielG.Cavalli@surrey.ac.ukUNSPECIFIED
Alpay, Esate.alpay@surrey.ac.ukUNSPECIFIED
Steinke, JHGUNSPECIFIEDUNSPECIFIED
Date : 24 June 2010
Identification Number : 10.1016/j.polymer.2010.04.026
Copyright Disclaimer : © 2010. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Science & Technology, Physical Sciences, Polymer Science, POLYMER SCIENCE, Poly(vinyl ether)s, Suspension polymerisation, Solid-phase synthesis, PHASE PEPTIDE-SYNTHESIS, PEG-DERIVED POLYETHERS, DIVERSE CONTRIBUTIONS, ORGANIC-SYNTHESIS, SOLUBLE POLYMERS, COMBINATORIAL, CHEMISTRY, TRANSFORMATIONS, PATTERN
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 16 Aug 2017 12:40
Last Modified : 16 Aug 2017 12:40
URI: http://epubs.surrey.ac.uk/id/eprint/795827

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