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Non-PEG-derived polyethers as solid supports. 1. Synthesis, swelling studies, and functionalization

Cavalli, G, Steinke, JHG, Shooter, AG and Pears, DA (2003) Non-PEG-derived polyethers as solid supports. 1. Synthesis, swelling studies, and functionalization Journal of Combinatorial Chemistry, 5 (5). pp. 637-644.

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Abstract

Novel non-PEG derived polyether resins, coined SLURPS (superior liquid-uptake resins for polymer-supported synthesis), were synthesized by cationic polymerization of vinyl ethers. A functional resin was prepared with excellent control over loading levels. A sequence of synthetic transformations involving the introduction of a Wang linker followed by Mitsunobu functionalization chemistry and cleavage of the bound substrate proceeded quantitatively. These new polymers combine outstanding swelling performance in a wide range of solvents with high chemical stability and tunable loading levels up to 8.5 mmol/g. This combination of desirable features sets them apart from other polymer supports and, in particular, other polyether resins currently investigated for combinatorial chemistry.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
AuthorsEmailORCID
Cavalli, GUNSPECIFIEDUNSPECIFIED
Steinke, JHGUNSPECIFIEDUNSPECIFIED
Shooter, AGUNSPECIFIEDUNSPECIFIED
Pears, DAUNSPECIFIEDUNSPECIFIED
Date : September 2003
Identification Number : 10.1021/cc0200686
Additional Information : This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher.To access the final edited and published work see http://dx.doi.org/10.1021/cc0200686.
Depositing User : Symplectic Elements
Date Deposited : 11 Sep 2013 08:01
Last Modified : 23 Sep 2013 20:15
URI: http://epubs.surrey.ac.uk/id/eprint/795245

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