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Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae)

Mulholland, Dulcie, Mwangi, EM, Dlova, NC, Plant, N, Crouch, NR and Coombes, PH (2013) Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae) JOURNAL OF ETHNOPHARMACOLOGY, 149 (2). pp. 570-575.

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Abstract

Ethnopharmacological relevance The stem bark of Garcinia livingstonei is used traditionally as a skin lightening agent. Aim of the study To isolate and identify compounds responsible for the observed skin lightening activity of Garcinia livingstonei and to evaluate their cytotoxicity. Materials and methods Constituents of the stem bark and fruits of Garcinia livingstonei were isolated using chromatographic techniques and structures were determined using 1D and 2D NMR and MS analysis. MeWo cells were used to evaluate the cytotoxicity and impact on melanin levels of extracts and compounds isolated, in vitro. Results Twelve known compounds, morelloflavone (1), morelloflavone-7″-sulphate (2), guttiferone A (3), sargaol (4), isojacareubin (5), 6-deoxyisojacareubin (6) and in addition to the common triterpenoids, betulin, betulin aldehyde, lupeol, lupenone, euphol and stigmasterol were isolated in this investigation. Morelloflavone, morelloflavone-7″-sulphate and sargaol, were found to be considerably less cytotoxic and more effective as skin lightening agents than hydroquinone. Conclusions A range of compounds was isolated from the stem bark and fruit of Garcinia livingstonei. Although the bark extract contained the cytotoxic guttiferone A, it was found to be less toxic than hydroquinone, and morelloflavone, the 7″-sulphate derivative and sargaol show potential for development as depigmentation/skin lightening agents.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Mulholland, DulcieD.Mulholland@surrey.ac.ukUNSPECIFIED
Mwangi, EMUNSPECIFIEDUNSPECIFIED
Dlova, NCUNSPECIFIEDUNSPECIFIED
Plant, NUNSPECIFIEDUNSPECIFIED
Crouch, NRUNSPECIFIEDUNSPECIFIED
Coombes, PHUNSPECIFIEDUNSPECIFIED
Date : 1 September 2013
Identification Number : 10.1016/j.jep.2013.07.023
Copyright Disclaimer : © 2013 Elsevier Ireland Ltd.
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Plant Sciences, Chemistry, Medicinal, Integrative & Complementary Medicine, Pharmacology & Pharmacy, CHEMISTRY, MEDICINAL, INTEGRATIVE & COMPLEMENTARY MEDICINE, PHARMACOLOGY & PHARMACY, PLANT SCIENCES, Garcinia livingstonei, Clusiaceae, Melanin production inhibitor, MeWo cells, Skin lightening agents, SKIN-LIGHTENING COSMETICS, SYMPHONIA-GLOBULIFERA, NATURAL-PRODUCTS, TYROSINASE INHIBITORS, EXOGENOUS OCHRONOSIS, TRADITIONAL MEDICINE, HYPERICUM-JAPONICUM, RHEEDIA-GARDNERIANA, PHENOLIC-COMPOUNDS, IN-VITRO
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Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Ethnopharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Ethnopharmacology, July 2013, DOI 10.1016/j.jep.2013.07.023.
Depositing User : Symplectic Elements
Date Deposited : 28 Aug 2013 13:19
Last Modified : 26 Jul 2017 08:02
URI: http://epubs.surrey.ac.uk/id/eprint/794980

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