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Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans.

Ackermann, K, Plomp, R, Lao, O, Middleton, B, Revell, VL, Skene, DJ and Kayser, M (2013) Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans. Chronobiol Int, 30 (7). pp. 901-909.

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Abstract

This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean ± SD: 23 ± 5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Ackermann, KUNSPECIFIEDUNSPECIFIED
Plomp, RUNSPECIFIEDUNSPECIFIED
Lao, OUNSPECIFIEDUNSPECIFIED
Middleton, BUNSPECIFIEDUNSPECIFIED
Revell, VLUNSPECIFIEDUNSPECIFIED
Skene, DJUNSPECIFIEDUNSPECIFIED
Kayser, MUNSPECIFIEDUNSPECIFIED
Date : August 2013
Identification Number : 10.3109/07420528.2013.784773
Related URLs :
Additional Information : This is an electronic version of an article published in Chronobiology International. Chronobiology International is available at http://informahealthcare.com/journal/cbi
Depositing User : Symplectic Elements
Date Deposited : 28 Aug 2013 13:55
Last Modified : 01 Aug 2014 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/794398

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