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Determination of biological vector characteristics and nanoparticle dimensions for radioimmunotherapy with radioactive nanoparticles.

Nuttens, VE, Wéra, AC, Bouchat, V and Lucas, S (2008) Determination of biological vector characteristics and nanoparticle dimensions for radioimmunotherapy with radioactive nanoparticles. Appl Radiat Isot, 66 (2). pp. 168-172.

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Abstract

Radioimmunotherapy with biological vector labeled with radioactive nanoparticles is investigated from a dosimetric point of view. Beta (32P, 90Y) and low-energy X-ray radionuclides (103Pd) are considered. Dose distributions inside solid tumors have been calculated using MCNPX 2.5.0. Nanoparticle dimensions and biological vector characteristics are also determined in order to reach the 50 Gy prescribed dose inside the entire tumor volume. The worst case of an avascular tumor is considered. Results show that for beta-emitting nanoparticles, a set of data (covering fraction, biological half-life, and nanoparticle radius) can be found within acceptable ranges (those of classical radioimmunotherapy). These sources (with Emax approximately few MeV) can be used for the treatment of tumors with a maximum diameter of about 1 cm. Low-energy X-rays (E<25 keV) can be used to extend the range of tumor diameter to 4-5 cm but require very tight biological vector characteristics.

Item Type: Article
Authors :
NameEmailORCID
Nuttens, VEUNSPECIFIEDUNSPECIFIED
Wéra, ACUNSPECIFIEDUNSPECIFIED
Bouchat, VUNSPECIFIEDUNSPECIFIED
Lucas, SUNSPECIFIEDUNSPECIFIED
Date : February 2008
Identification Number : 10.1016/j.apradiso.2007.08.017
Uncontrolled Keywords : Humans, Metal Nanoparticles, Neoplasms, Palladium, Phosphorus Radioisotopes, Radioimmunotherapy, Radioisotopes, Radiopharmaceuticals, Radiotherapy Dosage, Yttrium Radioisotopes
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 13:48
Last Modified : 31 Oct 2017 15:06
URI: http://epubs.surrey.ac.uk/id/eprint/787678

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