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Flavan-3-ols from the leaves of Malaysian Uncaria longiflora var. pteropoda (Miq.) Ridsd

Salim, F, Zain, MM, Ahmad, R, Ridzuan, MSM, Langat, MK and Mulholland, DA (2013) Flavan-3-ols from the leaves of Malaysian Uncaria longiflora var. pteropoda (Miq.) Ridsd Phytochemistry Letters, 6 (2). pp. 236-240.

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Abstract

A novel flavonoid, (-)-2R,3R-3,5,4′-trihydoxyflavan-[6,7:5″, 6″]-2″-pyranone, named uncariechin (1), was isolated from the methanolic extract of the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsd. along with the known (-)-epiafzelechin (2) and (-)-epicatechin (3), methyl 4-hydroxybenzoate and 4-hydroxybenzaldehyde, four pentacyclic oxindole alkaloids, isopteropodine, pteropodine, uncarine F and isopteropodic acid, previously found in the stems, and two coumarins, scopoletin and 3,4-dihydroxy-7-methoxycoumarin. Structures of the compounds were elucidated by 1D and 2D NMR, FTIR, UV, MS, and experimental as well as calculated electronic circular dichroism (ECD) data. Compounds 2 and 3 were evaluated for their neurotoxic and neuroprotective properties against differentiated SH-SY5Y neuroblastoma cell lines using the MTS assay. Compounds 2 and 3 did not show any neurotoxic effects but showed strong protective potential against hydrogen peroxide-induced neurotoxicity with maximum cell viability at a concentration of 1 μM. © 2013 Phytochemical Society of Europe.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
AuthorsEmailORCID
Salim, FUNSPECIFIEDUNSPECIFIED
Zain, MMUNSPECIFIEDUNSPECIFIED
Ahmad, RUNSPECIFIEDUNSPECIFIED
Ridzuan, MSMUNSPECIFIEDUNSPECIFIED
Langat, MKUNSPECIFIEDUNSPECIFIED
Mulholland, DAUNSPECIFIEDUNSPECIFIED
Date : May 2013
Identification Number : 10.1016/j.phytol.2013.02.007
Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Phytochemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Phytochemistry Letters, 6(2), May 2013, DOI 10.1016/j.phytol.2013.02.007.
Depositing User : Symplectic Elements
Date Deposited : 15 Aug 2013 08:47
Last Modified : 23 Sep 2013 20:10
URI: http://epubs.surrey.ac.uk/id/eprint/782617

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