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Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays

Wéra, A-C, Borlon, C, Nuttens, VE, Lucas, S, Riquier, H, Michiels, C and Feron, O (2012) Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays International Journal of Radiation Biology, 88 (3). pp. 253-257.

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Abstract

Purpose: Lung cancer is the leading cause of cancer-related death. Among the new modalities to treat cancer, internal radiotherapy seems to be very promising. However, the achievable dose-rate is two orders of magnitude lower than the one used in conventional external radiotherapy, and data has to be collected to evaluate the cell response to highlight the potential effectiveness of low-dose-rate beta particles irradiation. This work investigates the phosphorus beta irradiation ( P) dose response on the clonogenicity of human A549 non-small cell lung adenocarcinoma cells and compares it to high-dose-rate X-irradiations results. Materials and methods: Cell survival was evaluated by a colony forming assay eight days after low-dose-rate P beta irradiations (0.8 Gy/h) and high-dose-rate X-ray irradiations (0.855 Gy/min). Results: Survival curves were obtained for both types of irradiations, and showed hyper-radiosensitivity at very low doses. Radiosensitivity parameters were obtained by using the linear-quadratic and induced-repair models. Conclusions: Comparison with high-dose-rate X-rays shows a similar surviving fraction, confirming the effectiveness of beta particles for tumor sterilization. © 2012 Informa UK, Ltd.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
AuthorsEmailORCID
Wéra, A-CUNSPECIFIEDUNSPECIFIED
Borlon, CUNSPECIFIEDUNSPECIFIED
Nuttens, VEUNSPECIFIEDUNSPECIFIED
Lucas, SUNSPECIFIEDUNSPECIFIED
Riquier, HUNSPECIFIEDUNSPECIFIED
Michiels, CUNSPECIFIEDUNSPECIFIED
Feron, OUNSPECIFIEDUNSPECIFIED
Date : March 2012
Identification Number : 10.3109/09553002.2012.643274
Additional Information : This is an electronic version of an article published in [ International Journal of Radiation Biology, March 2012, Vol. 88, No. 3 : Pages 253-257] International Journal of Radiation Biology is available at http://informahealthcare.com/journal/rab
Depositing User : Symplectic Elements
Date Deposited : 11 Jul 2013 09:36
Last Modified : 09 Jun 2014 13:51
URI: http://epubs.surrey.ac.uk/id/eprint/782410

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