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Preliminary results of proton beam characterization for a facility of broad beam in vitro cell irradiation

Wéra, A-C, Lucas, S, Donato, K, Jongen, Y and Michiels, C (2008) Preliminary results of proton beam characterization for a facility of broad beam in vitro cell irradiation Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 266 (10). pp. 2122-2124.

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Abstract

The interaction of charged particles with living matter needs to be well understood for medical applications. Particularly, it is useful to study how ion beams interact with tissues in terms of damage, dose released and dose rate. One way to evaluate the biological effects induced by an ion beam is by the irradiation of cultured cells at a particle accelerator, where cells can be exposed to different ions at different energies and flux. In this paper, we report the first results concerning the characterization of a broad proton beam obtained with our 2 MV tandem accelerator. For broad beam in vitro cell irradiation, the beam has to be stable over time, uniform over a ∼0.5 cm surface, and a dose rate ranging from 0.1 to 10 Gy/min must be achievable. Results concerning the level of achievement of these requirements are presented in this paper for a 1 MeV proton beam. © 2008 Elsevier B.V. All rights reserved.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
AuthorsEmailORCID
Wéra, A-CUNSPECIFIEDUNSPECIFIED
Lucas, SUNSPECIFIEDUNSPECIFIED
Donato, KUNSPECIFIEDUNSPECIFIED
Jongen, YUNSPECIFIEDUNSPECIFIED
Michiels, CUNSPECIFIEDUNSPECIFIED
Date : May 2008
Identification Number : 10.1016/j.nimb.2008.02.066
Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 266(10), May 2008, DOI 10.1016/j.nimb.2008.02.066.
Depositing User : Symplectic Elements
Date Deposited : 11 Jul 2013 09:24
Last Modified : 23 Sep 2013 20:10
URI: http://epubs.surrey.ac.uk/id/eprint/782409

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