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In vitro irradiation station for broad beam radiobiological experiments

Wéra, A-C, Heuskin, A-C, Lucas, S, Riquier, H and Michiels, C (2011) In vitro irradiation station for broad beam radiobiological experiments Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 269 (24). pp. 3120-3124.

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Abstract

The study of the interaction of charged particles with living matter is of prime importance to the fields of radiotherapy, radioprotection and space radiobiology. Particle accelerators and their associated equipment are proven to be helpful tools in performing basic science in all these fields. Indeed, they can accelerate virtually any ions to a given energy and flux and let them interact with living matter either in vivo or in vitro. In this context, the University of Namur has developed a broad beam in vitro irradiation station for use in radiobiological experiments. Cells are handled in GLP conditions and can be irradiated at various fluxes with ions ranging from hydrogen to carbon. The station is mounted on a 2 MV tandem accelerator, and the energy range can be set up in the linear energy transfer (LET) ranges that are useful for radiobiological experiments. This paper describes the current status of the hardware that has been developed, and presents results related to its performance in term of dose-rate, energy range and beam uniformity for protons, alpha particles and carbon ions. The results of clonogenic assays of A549 lung adenocarcinoma cells irradiated with protons and alpha particles are also presented and compared with literature. © 2011 Elsevier B.V. All rights reserved.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
AuthorsEmailORCID
Wéra, A-CUNSPECIFIEDUNSPECIFIED
Heuskin, A-CUNSPECIFIEDUNSPECIFIED
Lucas, SUNSPECIFIEDUNSPECIFIED
Riquier, HUNSPECIFIEDUNSPECIFIED
Michiels, CUNSPECIFIEDUNSPECIFIED
Date : 15 December 2011
Identification Number : 10.1016/j.nimb.2011.04.104
Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 269(24), December 2011, DOI 10.1016/j.nimb.2011.04.104.
Depositing User : Symplectic Elements
Date Deposited : 11 Jul 2013 09:05
Last Modified : 23 Sep 2013 20:10
URI: http://epubs.surrey.ac.uk/id/eprint/782408

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