University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Do SCFA have a role in appetite regulation?

Darzi, J, Frost, GS and Robertson, MD (2011) Do SCFA have a role in appetite regulation? Proc Nutr Soc, 70 (1). pp. 119-128.

[img] Text
Darzi et al (2011) PNS 70 119-128.pdf
Restricted to Repository staff only
Available under License : See the attached licence file.

Download (339kB)
[img] Text (licence)
Restricted to Repository staff only

Download (33kB)


The recently discovered SCFA-activated G-coupled protein receptors FFA receptor 2 and FFA receptor 3 are co-localised in l-cells with the anorexigenic 'ileal brake' gut hormone peptide YY, and also in adipocytes, with activation stimulating leptin release. Thus, SCFA such as acetate and propionate show promise as a candidate to increase satiety-enhancing properties of food. We therefore postulate SCFA may have a role in appetite regulation and energy homeostasis. SCFA can be delivered either directly within food, or indirectly via the colon by the provision of fermentable non-digestible carbohydrates. A review of studies investigating the effects of oral SCFA ingestion on appetite suggests that while oral SCFA ingestion is associated with enhanced satiety, this may be explained by product palatability rather than a physiological effect of SCFA. Colon-derived SCFA generated during microfloral fermentation have also been suggested to explain satiety-enhancing properties of non-digestible carbohydrates. However, findings are mixed from investigations into the effects of the prebiotic inulin-type fructans on appetite. Overall, data presented in this review do not support a role for SCFA in appetite regulation.

Item Type: Article
Divisions : Surrey research (other units)
Authors : Darzi, J, Frost, GS and Robertson, MD
Date : February 2011
DOI : 10.1017/S0029665110004039
Uncontrolled Keywords : Appetite Regulation, Colon, Dietary Fats, Dietary Fiber, Fatty Acids, Volatile, Gastrointestinal Hormones, Humans, Prebiotics, Satiation, Taste
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 13:48
Last Modified : 24 Jan 2020 12:01

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800