Dietary fibre improves first-phase insulin secretion in overweight individuals.
Bodinham, CL, Smith, L, Wright, J, Frost, GS and Robertson, MD (2012) Dietary fibre improves first-phase insulin secretion in overweight individuals. PLoS One, 7 (7).
Available under License : See the attached licence file.
Previous work has shown increased insulin sensitivity, increased hepatic insulin clearance and lower postprandial insulin responses following treatment with resistant starch, a type of dietary fibre. The objective of this study was to further explore the effects of resistant starch on insulin secretion. Twelve overweight (BMI 28.2±0.4 kg/m(2)) individuals participated in this randomized, subject-blind crossover study. Participants consumed either 40 g type 2 resistant starch or the energy and carbohydrate-matched placebo daily for four weeks. Assessment of the effect on insulin secretion was made at the end of each intervention using an insulin-modified frequently sampled intravenous glucose tolerance test (FSIVGTT). Insulin and C-peptide concentrations were significantly higher during the FSIVGTT following the resistant starch compared with the placebo. Modelling of the data showed significantly improved first-phase insulin secretion with resistant starch. These effects were observed without any changes to either body weight or habitual food intake. This study showed that just four weeks of resistant starch intake significantly increased the first-phase insulin secretion in individuals at risk of developing type 2 diabetes. Further studies exploring this effect in individuals with type 2 diabetes are required.
|Divisions :||Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences|
|Identification Number :||10.1371/journal.pone.0040834|
|Additional Information :||: � 2012 Bodinham et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The original article can be found at http://dx.doi.org/10.1371/journal.pone.0040834|
|Depositing User :||Symplectic Elements|
|Date Deposited :||26 Jun 2013 08:06|
|Last Modified :||23 Sep 2013 20:08|
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