DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development
Yang, J, Wu, C-Y and Adams, M (2013) DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development Granular Matter. pp. 1-10.
Available under License : See the attached licence file.
Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method, which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criterion is proposed to determine the lowest impact velocity at which two elastic autoadhesive spherical particles will rebound from each other during impact. Furthermore, the process of fine API particles adhering to a large carrier in a vibrating container is investigated. It was found that there are optimal amplitude and frequency for the vibration velocity that can maximise the number of particles contacting with the carrier (i.e. the contact number). The impact number and detachment number during the vibration process both increase with increasing vibration amplitude and frequency while the sticking efficiency decreases as the amplitude and frequency are increased. © 2013 Springer-Verlag Berlin Heidelberg.
|Divisions :||Faculty of Engineering and Physical Sciences > Chemical and Process Engineering|
|Identification Number :||https://doi.org/10.1007/s10035-013-0405-0|
|Additional Information :||The original publication is available at http://link.springer.com/article/10.1007%2Fs10035-013-0405-0|
|Depositing User :||Symplectic Elements|
|Date Deposited :||05 Jun 2013 08:49|
|Last Modified :||23 Sep 2013 20:07|
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