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DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development

Yang, J, Wu, C-Y and Adams, M (2013) DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development Granular Matter. pp. 1-10.

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Abstract

Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method, which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criterion is proposed to determine the lowest impact velocity at which two elastic autoadhesive spherical particles will rebound from each other during impact. Furthermore, the process of fine API particles adhering to a large carrier in a vibrating container is investigated. It was found that there are optimal amplitude and frequency for the vibration velocity that can maximise the number of particles contacting with the carrier (i.e. the contact number). The impact number and detachment number during the vibration process both increase with increasing vibration amplitude and frequency while the sticking efficiency decreases as the amplitude and frequency are increased. © 2013 Springer-Verlag Berlin Heidelberg.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
AuthorsEmailORCID
Yang, JUNSPECIFIEDUNSPECIFIED
Wu, C-YUNSPECIFIEDUNSPECIFIED
Adams, MUNSPECIFIEDUNSPECIFIED
Date : 2013
Identification Number : 10.1007/s10035-013-0405-0
Additional Information : The original publication is available at http://link.springer.com/article/10.1007%2Fs10035-013-0405-0
Depositing User : Symplectic Elements
Date Deposited : 05 Jun 2013 08:49
Last Modified : 23 Sep 2013 20:07
URI: http://epubs.surrey.ac.uk/id/eprint/772687

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